Overview

Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided. Features: Highlights emerging scientific fields relevant to drug discovery such as the microbiome, nanotechnology, and cancer immunotherapy; and novel research tools such as CRISPR and DNA-encoded libraries Case study detailing the discovery of the anti-cancer drug, lorlatinib Venture capitalist commentary on trends and best practices in drug discovery and development Comprehensive review of regulations and their impact on drug development, highlighting special populations, orphan drugs, and pharmaceutical compounding Multidiscipline functioning of an Academic Research Enterprise, plus a chapter on Ethical Concerns in Research Contributions by 70+ experts from industry and academia specialists who developed and are practitioners of the science and business

Full Product Details

Author:   James J. O'Donnell ,  John Somberg (AM Inst Therapeutics, Lake Bluff, IL USA) ,  Vincent Idemyor (Chicago, Illinois, USA) ,  James T. O'Donnell (Rush University Medical Center, Chicago, Illinois, USA)
Publisher:   Taylor & Francis Ltd
Imprint:   CRC Press
Edition:   3rd edition
Weight:   1.283kg
ISBN:  

9781032084244

ISBN 10:   1032084243
Pages:   696
Publication Date:   30 June 2021
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Acknowledgments Introduction to the First Edition (1992) Introduction to the Second Edition (2006) Editors Contributors Chapter 1: Introduction to Drug Discovery and Development James J. O’Donnell III, John C. Somberg, and James T. O’Donnell SECTION I Overview Chapter 2: Current Opinions on the Trajectory of the Pharmaceutical Development John C. Somberg Chapter 3: Innovation in Drug Development: Perspectives of a Venture Capitalist Krishna Yeshwant SECTION II Drug Discovery Chapter 4: High-Throughput Screening Olivia Perez, J. Pena, Virneliz Fernandez-Vega, Louis Scampavia, and Timothy Spicer Chapter 5: DNA-Encoded Compound Libraries: An Emerging Paradigm in Drug Hit Discovery Raphael M. Franzini Chapter 6: Bio-Targeted Nanomaterials for Theranostic Applications Sabyasachi Maiti and Kalyan Kumar Sen Chapter 7: The Development of Adoptive T-Cell Immunotherapies for Cancer: Challenges and Prospects David J. Dow, Steven J. Howe, Mala K. Talekar, and Laura A. Johnson Chapter 8: CRISPR in Drug Discovery Chih-Shia Lee and Ji Luo Chapter 9: Probiotics in the World: “Bugs-as-Drugs” Thomas Kuntz, Madeline Kim, Elle Simone Hill, Mariana C. Salas Garcia, and Jack A. Gilbert Chapter 10: Discovery and Early Development of the Next-Generation ALK Inhibitor, Lorlatinib (18): Agent for Non·Small-Cell Lung Cancer Paul F. Richardson SECTION III Drug Development Chapter 11: Integrated Drug Product Development: From Lead Candidate Selection to Life-Cycle Management Madhu Pudipeddi, Abu T.M. Serajuddin, Ankita V. Shah, and Daniel Mufson Chapter 12: New Trends in Pharmacological and Pharmaceutical Profiling Lyn Rosenbrier Ribeiro, Duncan Armstrong, Thierry Jean, and Jean-Pierre Valentin Chapter 13: Pharmacokinetics·Pharmacodynamics in New Drug Development Sarfaraz K. Niazi Chapter 14: The Evolving Role of the Caco-2 Cell Model to Estimate Intestinal Absorption Potential and Elucidate Transport Mechanisms Jibin Li and Ismael J. Hidalgo Chapter 15: Preclinical Toxicology Damani Parran Chapter 16: Safety Pharmacology: Past, Present, and Future Jean-Pierre Valentin, Annie Delaunois, Marie-Luce Rosseels, Vitalina Gryshkova, and Tim G. Hammond Chapter 17: Ethical Concerns in Clinical Research Jonathan C. Young and Lori Nesbitt Chapter 18: Clinical Trials Methodology John Somberg Chapter 19: The Academic Research Enterprise Crista Brawley, Mary Jane Welch, Jeff Oswald, Erin Kampschmidt, Jennifer Garcia, Allecia Harley, Shrijay Vijayan, John McClatchy, Stephanie Guzik, and Stephanie Tedford Chapter 20: Clinical Testing Challenges in HIV/AIDS Research Vincent Idemyor Chapter 21: The Evolving Role of the Pharmacist in Clinical, Academic, and Industry Sectors Gourang Patel and Stephanie Tedford Chapter 22: Intellectual Property in the Drug Discovery Process Martha M. Rumore and William Schmidt Chapter 23: Drug Repurposing: Academic Clinician Research Endeavors Kathleen Heneghan and Stephanie E. Tedford SECTION IV Regulations Chapter 24: The Role of the Regulatory Affairs Professional in Guiding New Drug Research, Development, and Approval S. Albert Edwards Chapter 25: Orphan Drug Development and Regulations A.M. Lynch Chapter 26: Development of Drug Products for Older Adults: Challenges, Solutions, and Regulatory Considerations S.W. Johnny Lau, Darrell R. Abernethy, and Chandrahas Sahajwalla Chapter 27: Clinical Pharmacology and Regulatory Concerns for Developing Drug Products for Pediatric Patients Janelle M. Burnham and Gilbert J. Burckart Chapter 28: Pharmacy Compounding Regulations Loyd V. Allen, Jr. and Willis C. Triplett Index

Reviews

This third edition, written by experts from around the world, is expected to be useful for scientists working in this field. Each team in the drug discovery and development group will find some useful information in this book. There are many books in this area, but this one appears to discuss the topics in a bit greater detail. - Rahmat M. Talukder, PhD, RPh (The University of Texas at Tyler

This third edition, written by experts from around the world, is expected to be useful for scientists working in this field. Each team in the drug discovery and development group will find some useful information in this book. There are many books in this area, but this one appears to discuss the topics in a bit greater detail. - Rahmat M. Talukder, PhD, RPh (The University of Texas at Tyler

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James J. O'Donnell, James T. O'Donnell

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