Overview

Dominant exudative vitreoretinopathy (DEVR) is an eye disease which has only recently received wider attention. In 1969 Criswick and Schepens used the designation ""familial exudative vitreoretinopathy"" to describe a syndrome they observed in six patients belonging to two families. The condition was characterized by several symptoms involving the vitreous and retina, e. g. ""posterior vitreous detachment, organized vitreous membranes, heterotopia of the macula, retinal neovascularizations, subretinal and intraretinal exudates, and localized retinal detachment"". The clinical features impressed the authors as strongly reminiscent of retrolental fibroplasia, but none of the patients had a record of premature birth or postnatal oxygen administration. In 1971 Cow and Oliver described the same syndrome in several members of one family. They considered their findings to be compatible with auto- somal dominant transmission. Canny and Oliver (I976) were the first to de- monstrate the fluorescein-angiographic changes of DEVR in four members of the abovementioned family. The most striking finding was ""abrupt cessation of the capillary network in a scaloped edge near the equator"". Fluorescein was seen to leak from the retinal vessels localized in this marginal zone, and in some eyes from massive fibrovascular lesions as well. Similar fluorescein- angiographic changes have been described in recent years in other reports on families with DEVR (Nijhuis et aI. , 1979; Slusher and Hutton, 1979; Dudgeon, 1979; Ober et a1. , 1980; Laqua, 1980). In 1979 I commenced a clinical study of this still little-known condition at the Nijmegen University Institute of Ophthalmology (The Netherlands).

Full Product Details

Author:   C.E. van Nouhuys
Publisher:   Springer
Imprint:   Springer
Edition:   Softcover reprint of the original 1st ed. 1982
Volume:   5
Dimensions:   Width: 15.50cm , Height: 2.20cm , Length: 23.50cm
Weight:   0.658kg
ISBN:  

9789400980235

ISBN 10:   940098023
Pages:   430
Publication Date:   08 October 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

I: The normal vasculature of the peripheral retina.- 1. Development and anatomy of the normal vasculature of the peripheral retina.- 2. Clinical examination of peripheral retinal blood vessels and circulation.- II: Disturbed development of the peripheral retinal vessels.- 3. Clinical studies of families with dominant exudative vitreoretinopathy.- 4. Results and discussion of the family studies.- 5. Genetic aspects and pathogenesis of dominant exudative vitreoretinopathy.- 6. Prevention and treatment of complications of dominant exudative vitreoretinopathy.- 7. Congenital retinal fold (ablatio falciformis congenita).- 8. Retrolental fibroplasia.- 9. Affections with congenital or neonatal vitreous organizations and retinal detachment.- 10. Observations on Wagner’s syndrome, sex-linked juvenile retinoschisis and juvenile rhegmatogenous retinal detachment.- 11. Congenital bilateral arterial anastomosis between the choroid and the peripheral retina.- 12. Coats’ disease and retinal angiomatosis.- III: Additional differential diagnoses from dominant exudative vitreoretinopathy.- 13. Congenital conditions not associated with retinal vascular developmental disorders.- 14. Acquired conditions.- Summary.- Samenvatting.- References.- Curriculum vitae.

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