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Author:   Rossen Donev (Head of Research, MicroPharm Limited, UK) ,  Rossen Delete Donev (Swansea University, UK) ,  Rossen Delete Donev (Swansea University, UK) ,  Rossen Delete Donev (Swansea University, UK)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Weight:   0.720kg
ISBN:  

9780128155592

ISBN 10:   0128155590
Pages:   383
Publication Date:   20 February 2019
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. DNA repair by photolyases Ibrahim Halil Kavakli, Nuri Ozturk and Seref Gul 2. TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair Olga Kolesnikova, Laura Radu, and Arnaud Poterszman 3. Chromatin control in double strand break repair Anastas Gospodinov and Iva Ugrinova 4. Controlling the balance between chromosome break repair pathways Sonia Jimeno, Fernando Mejías-Navarro, Rosario Prados-Carvajal and Pablo Huertas 5. Targeting DNA repair in precision medicine Reena Beggs and Eddy S. Yang 6. Replication stress: Driver and therapeutic target in genomically instable cancers Pepijn M. Schoonen, Sergi Guerrero Llobet and Marcel A.T.M. van Vugt 7. Claspin: From replication stress and DNA damage responses to cancer therapy Diana Azenha, Maria Celeste Lopes and Teresa C. Martins 8. cAMP-mediated regulation of melanocyte genomic instability: A melanoma-preventive strategy Nathaniel C. Holcomb, Robert-Marlo Bautista, Stuart G. Jarrett, Madeline Krentz Gober, Katharine M. Carter and John A. D’Orazio 9. Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling Shibani Mukherjee, Salim Abdisalaam, Souparno Bhattacharya, Kalayarasan Srinivasan, Debapriya Sinha and Aroumougame Asaithamby 10. Elucidating the role of interacting residues of the MSH2-MSH6 complex in DNA repair mechanism: A computational approach D. Thirumal Kumar, B. Susmita, E. Judith, J. Priyadharshini Christy, C. George Priya Doss and Hatem Zayed 11. A computational model to predict the structural and functional consequences of missense mutations in O6-methylguanine DNA methyltransferase Thirumal Kumar D., Enid Mendonca, J. Priyadharshini Christy, C. George Priya Doss and Hatem Zayed

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Author Information

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.

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