Overview

This book provides a broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. It describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour. It also provides a comprehensive insightful look at the molecular players involved in DNA methylation, histone modification and chromatin remodelling complexes causing epigenetic lesions linked to the metastasic phenotypes. Finally, it explains how epigenetic lesions associated with cancer spreading can be targeted using new and potent chemotherapy drugs. The book is a state-of-the-art reference to all scientific researchers and clinicians interested in the understanding of the biological processes leading to tumor dissemination and to those that are keen to translate this knowledge to a better management of cancer patients. Each contributor is a specialist in their epigenetic area and their joint effort has created a unique view of the DNA methylation, histone and chromatin changes that define cancer metastasis.

Full Product Details

Author:   Manel Esteller
Publisher:   Springer
Imprint:   Springer
Edition:   Softcover reprint of hardcover 1st ed. 2005
Volume:   7
Dimensions:   Width: 16.00cm , Height: 1.70cm , Length: 24.00cm
Weight:   0.520kg
ISBN:  

9789048169177

ISBN 10:   9048169178
Pages:   310
Publication Date:   22 October 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Chapter 1: How CpG Island Hypermethylation Leads to Cancer Dissemination: The Sounds of Silence for Tumor and Metastasis Suppressor Genes. Manel Esteller Chapter 2: A Mouse Skin Multistage Carcinogenesis Model that Unmasks Epigenetic Lesions Responsible for Metastasis. Mario F. Fraga & Manel Esteller Chapter 3: CpG Island Hypermethylation and Lung Cancer Invasion and Metastasis. Ubaradka G. Sathyanarayana & Adi F. Gazdar Chapter 4: CpG Island Hypermethylation Changes During Prostate Cancer Progression and Metastasis. Srinivasan Yegnasubramanian & William G. Nelson Chapter 5: CpG Island Hypermethylation in Breast Cancer Progression and Metastasis. Paola Parrella Chapter 6: Epigenettic Dysregulation of Maspin (SerpinB5) in Cancer Invasion and Metastasis. Bernard W. Futscher & Frederick E. Domann Chapter 7: Epigenetic Regulation of the E-cadherin Cell-Cell Adhesion Gene. Hector Peinado & Amparo Cano Chapter 8: Epigenetic Disruption of the SLIT-ROBO Interactions in Human Cancer. Ashraf Dallol, Rachel E. Dickinson & Farida Latif Chapter 9: Molecular Mechanisms of the Metastasis-Associated Gene Family of Coregulators: Role in Cancer and Invasion. Seetharaman Balasenthil & Rakesh Kumar Chapter 10: The Molecular Mechanisms for BRMS1 Action in Cancer Metastasis. Rajeev S. Samant & Lalita A. Shevde Chapter 11: Mechanisms of DNA Demethylating Drugs Against Cancer Progression. Zunyan Dai, Kavitha Kosuri & Gregory A. Otterson Chapter 12: Histone Deacetylase Inhibitors: Novel Targeted Anti-Cancer Agents. Paul Marks & William Kevin Kelly.

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