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OverviewDNA Damage and Chromosomal Instability, Volume 182 in the Methods in Cell Biology series, presents interesting chapters on a variety of timely topics, including Induction of chromosome-specific micronuclei and chromothripsis by centromere inactivation, Generation of aneuploid cells and assessment of their ability to survive in presence of chemotherapeutic agents, Genetic reporters to detect and quantify homologous recombination in yeast, Mapping histone variant genomic distribution: exploiting SNAP- Tag labelling to follow the dynamics of incorporation of H3 variants, Enrichment of DNA replication intermediates by EdU pull down, Nascent DNA sequencing and its diverse applications in genome integrity research, and much more. Additional chapters cover Enrichment of DNA replication intermediates by EdU pull down, DNA curtains for studying phase separation mechanisms of DNA-organizing proteins, Visualizing the Dynamics of DNA Replication and Repair at the Single-Molecule Molecule Level, Cloning and Expansion of Repetitive DNA Sequences, Using an ImageJ-based script to detect replication stress and associated cell cycle exit from G2 phase by fluorescence microscopy Arne Lindqvist Full Product DetailsAuthor: Christian Zierhut , Lorenzo Galluzzi (Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USA)Publisher: Elsevier Science Publishing Co Inc Imprint: Academic Press Inc Weight: 0.450kg ISBN: 9780443188985ISBN 10: 044318898 Pages: 318 Publication Date: 12 February 2024 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Not yet available  This item is yet to be released. You can pre-order this item and we will dispatch it to you upon its release. Table of Contents1. Induction of chromosome-specific micronuclei and chromothripsis by centromere inactivation Peter Ly 2. Generation of aneuploid cells and assessment of their ability to survive in presence of chemotherapeutic agents Stefano Santaguida 3. Genetic reporters to detect and quantify homologous recombination in yeast Loraine Symington 4. Mapping histone variant genomic distribution: exploiting SNAP- Tag labelling to follow the dynamics of incorporation of H3 variants Geneviève Almouzni and Jean-Pierre Quivy 5. Nascent DNA sequencing and its diverse applications in genome integrity research Andre Nussenzweig and Jacob Paiano 6. Enrichment of DNA replication intermediates by EdU pull down Ylli Doksani 7. DNA curtains for studying phase separation mechanisms of DNA-organizing proteins Johannes Stigler 8. Visualizing the Dynamics of DNA Replication and Repair at the Single-Molecule Molecule Level Gheorghe Chistol 9. Cloning and Expansion of Repetitive DNA Sequences Gideon Coster and Sophie Lyn Williams 10. Using an ImageJ-based script to detect replication stress and associated cell cycle exit from G2 phase by fluorescence microscopy Arne Lindqvist 11. An automated image analysis pipeline to quantify the coordination and overlap of transcription and replication activity in mammalian genomes Stephan Hamperl 12. Monitoring Chk1 kinase activity dynamics in live single cell imaging assays Olivier Gavet and Vicente Lebrec 13. Visualising DNA damage and repair using single molecule super resolution microscopy Donna Whelan 14. Quantification of nuclear deformations and DNA damage foci dynamics by live-cell imaging Francisca Lottersberger 15. Native FISH: A low- and high- throughput assay to analyze the Alternative Lengthening of Telomere (ALT) pathway Eros Lazzerini-Denchi and Benura Azeroglu 16. Assessment of DNA Fibres Chris Staples 17. A high-content flow cytometry and dual CRISPR-Cas9 based platform to quantify genetic interactions Priyanka Verma 18. Monitoring APOBEC3A protein levels in human cancer cells John MaciejowskiReviewsAuthor InformationLorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology. Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals: OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience. Tab Content 6Author Website:Countries AvailableAll regions |
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