Overview

Full Product Details

Author:   P. L. Chambers ,  P. Preziosi ,  C. M. Chambers
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Volume:   7
Dimensions:   Width: 18.90cm , Height: 2.80cm , Length: 24.60cm
Weight:   1.062kg
ISBN:  

9783540124528

ISBN 10:   3540124527
Pages:   538
Publication Date:   01 October 1984
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock  
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

Plenary Lecture: Drug-Induced Cardionecrosis.- Young Scientists Award Lecture 1983: Investigations into the Mechanism of Coumarin-Induced Hepatotoxicity in the Rat.- Alteration of Drug Toxicity in Disease States.- Influence of Disease on Drug Toxicity.- Drug Toxicity and Hormonal Dysfunction.- Alterations of Drug Toxicity in Neuropsychiatric Disease States.- Alterations of Drug Toxicity in Cardiovascular Disease.- The Diseased Lung and Drugs.- Lead in Cerebrospinal Fluid in Cerebrovascular Disease: Its Possible Diagnostic, Prognostic and Toxic Significance.- A Comparative Study of Acute Toxicity of Drugs Used During Anticancer Therapy in Healthy and Tumor-Bearing Mice.- Antitumour Drug Toxicity in Pituitary or Adrenal-Ablated Rats.- Tolerance to Pituitary-Adrenal Axis Activation by Anticancer Drugs in Normal and Tumour-Bearing Rats.- Toxins in Hepatic Encephalopathy: The Role of the Synergistic Effect of Ammonia, Mercaptans and Short Chain Fatty Acids.- Toxic Effects on the Male Reproductive System.- Effects of Drugs and Chemicals on Spermatogenesis.- Assessment of Chemicals Affecting the Male Reproductive System.- Toxic and Mutagenic Influences on Spermatogenesis.- Gonadal Damage in Hodgkin's Disease from Cancer Chemotherapeutic Regimens.- Approaches to the Suppression of Testicular Function for Male Fertility Control.- Morphological Changes Produced in Rat Testis by Anticancer Drugs.- Aspects of Testicular Toxicity Induced by Anticancer Drugs.- Changes in Germinal Tissue and Leydig Cells Correlated with Ethanol Consumption in Males with and without Liver Disease.- Testicular Effects of Some Xanthine Derivatives in the Rat.- Effects of Daily High Doses of Paracetamol Given Orally During Spermatogenesis in Rat Testes.- The Effects on the Rat Testis of Single Inhalation Exposures to Ethylene Glycol Monoalkyl Ethers, in Particular Ethylene Glycol Monomethyl Ether.- Effects of an Indenopyridine Derivative, Compound 20-438, on Spermatogonial Stem Cells of the Rat.- Monitoring Chemically Induced DNA Damage in the Germ Cells of Male Mice.- Accumulation of Toxic Metals in Male Reproduction Organs.- Metabolism and Toxicity.- Active Metabolites in Toxicology: The Role of Cytochrome P-448 and Flavoprotein Oxidases.- The Role of Pharmacokinetics in the Design and Interpretation of Toxicological Studies.- Structural Characteristics of Compounds That can be Activated to Chemically Reactive Metabolites: Use for a Prediction of a Carcinogenic Potential.- Covalent Binding to Proteins as a Mechanism of Chemical Toxicity.- Species Differences in Oxidative Drug Metabolism: Some Basic Considerations.- Human Pharmacokinetics and Safety of Boric Acid.- The Influence of Paracetamol on the Hepatic Biosynthesis of Lecithin.- Decreased Blood Levels of Ethanol and Acetaldehyde by S-Adenosyl-L-Methionine in Humans.- Metabolic Activation of 2-Aminofluorene in the Salmonella Mutagenicity Assay by Different S-9 Preparations.- Reduction of Covalent Binding of Aflatoxin B1 to Rabbit Liver DNA After Immunization Against this Carcinogen.- Inactivation of 2-Amino-3-methyl-imidazo (4,5-f) quinoline by Horse Radish and Intestinal Peroxidase.- The Influence of Two Histamine H2-Receptor Antagonists, Cimetidine and Ranitidine, on the Plasma Levels and Clinical Effect of Nifedipine and Metoprolol.- Autoradiography of 2,4?,5-Trichlorobiphenyl Mercapturic Acid Indicates the Formation of Methyl Sulphone Metabolites with Selective Affinity for the Bronchial Mucosa.- Methadone Affects the Histochemical Pattern of Xenobiotic-Metabolizing Enzymes in the Liver of Pregnant Rats.- The Effects of Acetylcysteine on Liver Glutathione Depletion and Hepatic Necrosis Induced by Acetaminophen in Mice.- Increased Microsomal Metabolism of n-Hexane in Rat Kidney and Liver After Inhalation of Isopropanol.- Dose-Dependent Pharmacokinetics of Clofibric Acid in the Non-human Primate.- Different Pathways of Chloroform Metabolism.- In Vitro Inhibition of Lysosomal Phospholipases by Aminoglycoside Antibiotics: A Comparative Study.- Erythrocyte-Dependent Metabolic Activation of Styrene and Induction of Sister Chromatid Exchange in Cultured Human Lymphocytes.- Interaction of Acrylonitrile with the Liver Mixed Function Oxidases.- Induction of Microsomal Enzymes after Inhalation of Methanol.- Erythromycin Estolate Impairs the Mitochondrial and Microsomal Calcium Homeostasis: Correlation with Hepatotoxicity.- Relationships Between the Pharmacokinetics of Carbon Tetrachloride Conversion to Carbon Dioxide and Chloroform and Liver Injury.- Distribution and Metabolism of 2-t-Butyl-4-methoxyphenol in the Everted Rat Gut Preparation.- Phenytoin Metabolites in Human Placental Tissue.- The Placental Transfer and Detection of 14C-Carmoisine Metabolites by HPLC Combined with a Radioactivity Monitor (RAM).- Toxicity of Non-steroidal Antirheumatic Drugs: Molecular Mechanisms and Clinical Assessment.- A Biochemical Basis for the Gastrointestinal Toxicity of Non-steroid Antirheumatoid Drugs.- Molecular Mechanisms of the Gastric Toxicity of Antirheumatic Drugs.- Mechanisms of the Nephrotoxicity of Non-steroidal Anti-inflammatory Drugs.- Clinical Assessment of the Renal Toxicity of Antirheumatic Drugs.- Central and Peripheral Haemodynamic Effects of Non-steroidal Anti-inflammatory Drugs in Man.- Indomethacin Induced Intestinal Toxicity is Blocked by Sodium Salicylate at 24 and 48 Hours Post Treatment.- The Preclinical Toxicity of Dazoxiben: A Specific Inhibitor of Thromboxane A2 Synthetase.- Species Differences in the Acute Toxicity of Non-steroidal Anti-inflammatory Compounds.- Heavy Metal Toxicity.- Renal Handling of Cadmium: A Study by Tubular Microinjections.- Cadmium Alters Arterial Baroreflex Control of Heart Rate in the Conscious Rat.- Inhibition of Aortic Vessel Adenosine Diphosphate Degradation by Cadmium and Mercury.- Embryotoxic Action Induced by Mercury Acetate in the Rat.- Cardiovascular Homeostasis in Rats Chronically Exposed to Mercuric Chloride.- The Effects of a Dose of Mercuric Chloride, Below the Acute Toxic Dose, on Haemostasis in Rats.- In Vitro Cytotoxicity of Nickel Chloride on a Human Pulmonary Epithelial Cell Line (A 549).- Changes in Endogenous Monoamine Levels of Rat Brain Induced by Tetraethyl Lead.- Levels of Monoamines in Different Regions of the Rat Brain in Heavy Metal Intoxication.- Xenobiotic Toxicology.- Experimental Evidence on the Pulmonary Carcinogenicity of Arsenic Trioxide.- Molecular Interaction of Acrylonitrile at Target Sites of Carcinogenicity in Rats.- Mutagenic Activity of Nitriloacetic Acid.- Neurotoxicity in Rats Dosed with Peppermint Oil and Pulegone.- Neurotoxicological Profile of Carbon Disulphide After Intraventricular Administration in Rats.- Immediate Effects of m-Xylene on the Human Central Nervous System.- Potentiation of Hexane and Organophosphate Neurotoxicities.- Behavioural and Electrocortical Spectrum Power Changes After Intraventricular Injection of Patulin in Rats.- The Effects of Radiological Contrast Media on the Reproduction System of the Rat.- Short-term Studies with the Cryptating Agent Hexaoxa-diaza-bicyclo-hexacosane in Rats.- Evaluation of the Toxicological Risk in Animals Following the Ingestion of Cheese Obtained from Milk with Added Formaldehyde.- The Influence of Soil Particle Adsorption on 2,3,7,8-Tetrachlorodibenzo-p-dioxin Biological Uptake in the Rabbit.- The Subchronic Toxicity of 3,5-Dinitro-4-chloro-?,?,?-trifluorotoluene in the Rat.- Trihalomethane in Drinking Waters: A Statistical Study.- Inhalation Toxicology: Correlation Between the Concentration of the Test Compound and the Exposure Time Using Carbon Tetrachloride.- Circulating Concentrations of Testosterone, Luteinizing Hormone and Follicle Stimulating Hormone in Male Rats After Inhalation of Methanol.- The Effect of Sodium Selenite on Respiratory Function in Mitochondria Isolated from Guinea Pig Heart.- Intestinal Absorption and Excretion of Thallium (201Tl) in the Rat.- Evaluation of Pollution Levels by Analysis of the Pesticide Residues in Algerian Sheep.- Miscellaneous Toxic Effects.- A 2?Guanidyl Derivative of Gentamicin (S86451) with Reduced Nephrotoxicity: Studies at Low and Medium Dose Levels in the Rat.- Tubular Regeneration in Rat Kidney Cortex During Treatment with Gentamicin at a Low Dose.- Aminoglycoside Antibiotics: A Study of Their Neurotoxic Effects at Peripheral Nerve Fibres.- The Use of Physostigmine in Heroin Overdose.- 4-Aminopyridine: An Anticurare and Reawakening Drug.- The Influence of Dose Schedules and Administration Routes on the Toxicity of Potential Antiviral Drugs.- Intramuscular Injections and Muscle Damage: Effects of Concentration, Volume, Injection Speed and Vehicle.- Evidence of an Interaction Between Opioids and Histaminergic Systems on Cannabis Sativa-Induced Catalepsy.- Fever Reaction of Rabbits After Repeated Intravenous Injections of Antigens.- Cardiovascular Effects of Tetanus Toxin After Systemic and Intraventricular Administration in Rats.- The Incidence of Drug Overdosage in Patients Admitted to General Hospitals in the Canary Islands.- The Toxic Effects of Clofibrate and Its Metabolite on Mammalian Skeletal Muscle: An Electrophysiological Study.- A Comparative Retrospective Analysis of Data from Short- and Long-Term Animal Toxicity Studies on 40 Pharmaceutical Compounds.- Cardiac Hypertrophy in the Dog and Rat Induced by Oxfenicine, an Agent Which Modifies Muscle Metabolism.- An Epidemic of a New Haemorrhagic Disease in Infants Attributable to Talcum Powder Contaminated with Warfarin in Ho-Chi-Minh Ville (Vietnam).- Stress, Drugs, and Pregnancy: Experimental Studies on Embryo-Foetal Toxicity.- Long-Lasting Hypothermic Effects of Vincristine in Rats.- Behavioural Changes in Rats After Prenatal Administration of Typical and Atypical Antidepressants.- Side Effects of Drugs Stimulating Prolactin Secretion on the Behavior of Male Rats.- Possible Adverse Effects on the Cardiovascular System of an Antiarrhythmic Drug Mexiletine.- Novel and New Techniques in Toxicology.- A Single Step Method for the Separation of Rat Liver Cytosolic Glutathione S-Transferase Isozymes.- In Vitro Mouse Fertilization as an Experimental Model for the Monitoring of Adverse Effects on Gametes and Gamete Fusion.- Repeat Dermal Models for Systemic Toxicity: A Comparison of the Rabbit, Rat and Guinea Pig.- A New Cation-Exchange and Thin Layer Chromatography Technique for the Identification of Pethidine in Urine.- Author Index.

Reviews

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions