Overview

The aim of this book is to provide the necessary perspective to stimulate investigators (both clinicians and basic scientists) to ask the appropriate questions in their own experiments and, in time, determine whether direct myocardial revascularization has a place in the treatment of coronary artery disease. The last five years have witnessed an increasing interest in the subject of transmyocardial revascularization (TMR). The ideas and concepts associated with this particular method of myocardial revascularization have changed dramatically over a short period of time. The original premise of ""de-evolving"" mammalian hearts to recreate a reptilian-like myocardial circulation by multiple channels through the myocardium has been almost completely dismissed. Now, the most popular notion is that there is an angiogenic response to myocardial channel making. It is this development of new blood vessels that is thought to be responsible for the apparent improvements in symptoms and blood flow. Along the way, the idea that a channel could stay open and allow blood to flow directly from the ventricular chamber has found little support. Rather than directly explore all of these issues and merely duplicate previously published articles, our aim was to take a novel approach: that is, to step back from these arguments and provide perspective from the vantage point of distance.

Full Product Details

Author:   Peter Whittaker ,  George S. Abela
Publisher:   Springer
Imprint:   Springer
Edition:   1999 ed.
Volume:   211
Dimensions:   Width: 15.50cm , Height: 1.40cm , Length: 23.50cm
Weight:   1.080kg
ISBN:  

9780792383987

ISBN 10:   0792383982
Pages:   202
Publication Date:   31 March 1999
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

1. Early Methods of Myocardial Revascularization.- 2. The Vineberg Procedure in the Era of Transmyocardial Revascularization A New Paradigm for an Old Operation.- 3. TMR: Is it Still a Physiological Impossibility?.- 4. Increased Perfusion Via Laser-Mediated Myocardial Channels? Importance of Appropriate Models and Endpoints.- 5. Physiology and Histology of Acute Myocardial Channels Made With Different Lasers.- 6. Potential Laser Wavelengths for Percutaneous Endomyocardial Revascularization.- 7. Initial Use of an Ultraviolet Laser for TMR.- 8. The First Clinical TMR Trial: Historical Perspective.- 9. Initial Clinical Experience With a Holmium: YAG Laser: A Case Study Demonstrating Increased Myocardial Perfusion.- 10. Nuclear Imaging Techniques for the Evaluation of TMLR.- 11. Myocardial Angiogenesis: Biology and Therapy.

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