Overview

The first part of this book introduces the array of tools currently in use in structure determination, originating from mathematical, computational and experimental approaches. It displays the variety and ingenuity of old and new phasing approaches developed to solve increasingly complex structures. Some of the papers focus on recent developments that have given older methods a new lease of life. Equally impressive are the presentations of more recent approaches which take advantage of experimental, mathematical and computational advances. The second part of the book focuses on applications to macromolecular structures, displaying the great progress that has been achieved in recent years. The book concludes with a series of presentations on the new developments, providing a view of current phasing methodologies.

Full Product Details

Author:   S. Fortier
Publisher:   Springer
Imprint:   Springer
Edition:   1998 ed.
Volume:   507
Dimensions:   Width: 15.50cm , Height: 3.00cm , Length: 23.50cm
Weight:   0.969kg
ISBN:  

9780792349495

ISBN 10:   0792349490
Pages:   526
Publication Date:   28 February 1998
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

The phase problem of x-ray crystallography: overview.- A simple introduction to direct methods.- An elementary introduction to direct methods.- A simple introduction to Patterson methods.- An introduction to probability theory.- Intensity statistics and normalization.- Invariants, seminvariants and phase relationships.- Sayre equation, tangent formula and SAYTAN.- Probabilistic phasing methods versus macromolecular crystallography.- to the use of non-crystallographic symmetry in phasing.- An introduction to maximum entropy in action.- Crystal structure refinement incorporating chemical information.- Location of heavy atoms by automated Patterson interpretation.- New applications of simulated annealing in crystallographic refinement.- Figures of merit for evaluating phases.- to density modification.- An integrated graphical user interface for crystallographic software.- Isomorphous replacement: a survey of recent developments.- A theoretical study on the measurability of Bijvoet differences in macromolecular crystals.- Multiwavelength anomalous diffraction in macromolecular crystallography.- The solvent contrast variation method.- Obtaining phases from electron microscopy for solving protein structures.- Solving a heavy-atom substructure by direct methods.- Direct methods in relation to isomorphous data.- Integration of direct methods with SIR techniques.- Direct methods of solving phase ambiguities in macromolecular structures.- Phase refinement.- On the use of partial structure information in ab initio direct methods.- Direct methods with electron microscope information.- Density modification and direct methods.- Molecular scene analysis and its role in protein structure determination.- Membrane proteins solved by electron microscopy and electron diffraction.- The phase problem: a problem in constrained global optimization.- Shake-and-Bake: applications and advances.- SHELX applications to macromolecules.- Ab initio determination of a low resolution molecular envelope by direct methods.- Model based very low resolution phasing.- Use of non-crystallographic symmetry for ab initio phasing of virus structures.- Direct methods, and the use of synchrotron radiation for macromolecular crystallography.- The likelihood based choice of priors in statistical approaches to the phase problem.- Developments in maximum entropy and likelihood.- Extending the resolving power of Shake-and-Bake.- Reinvestigation of the use of Patterson maps to extrapolate data to higher resolution.- Intensity oversampling from crystallographic sampling via discrete Hilbert transforms.- Applications of direct methods with single isomorphous replacement or one wavelength anomalous scattering data.- Direct methods and molecular replacement techniques: the translation problem.- Holographic methods in x-ray crystallography.- A comparison of two algorithms for electron density map improvement by introduction of atomicity: skeletonization, and map sorting followed by refinement.- Real-space refinement using RsRef.- Towards the enantiomorph specific probabilistic theory of the structure invariants.

Reviews

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions