Overview

Aerobic organisms have evolved to utilise the intrinsic oxidising power of oxygen from the atmosphere. This so-called 'activation' of oxygen is often catalysed by a heme-containing enzyme. This book highlights the many and varied catalytic activities of O2-dependent heme–iron enzymes, including monoxygenases and cytochrome P450, dioxygenases, oxidases and model heme systems. Dioxygen-dependent Heme Enzymes will be a useful resource for postgraduate students and researchers in biochemistry and metallobiology working in, or moving into, research areas involving heme proteins.

Full Product Details

Author:   Masao Ikeda-Saito (Tohoku University, Japan) ,  Emma Raven (University of Bristol, UK) ,  Jiangyun Wang ,  Samuel de Visser
Publisher:   Royal Society of Chemistry
Imprint:   Royal Society of Chemistry
Volume:   Volume 13
Weight:   0.771kg
ISBN:  

9781782629917

ISBN 10:   1782629912
Pages:   408
Publication Date:   03 October 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Dioxygen Binding and Activation Mediated by Transition Metal Porphyrinoid Complexes; Design and Engineering of Heme Enzymes With O2-dependent Catalytic Activity; Myoglobin Derivatives Reconstituted with Modified Metal Porphyrinoids as Structural and Functional Models of the Cytochrome P450 Enzymes; Investigating Heme Enzymes with Expanded Genetic Codes; What Drives the Ratedetermining Step for Oxygen Atom Transfer by Heme Compound I?; Cytochrome P450 Decarboxylases; Oxygen Activation and Long-range Electron Transfer in MauG; Biological Heme Degradation; Structure, Function and Regulation of Human Heme-based Dioxygenases; Modeling O2-dependent Heme Enzymes: A Quick Guide for Non-experts; Structures of Human Cytochrome P450 Enzymes: Variations on a Theme; Controlling the Regio- and Stereoselectivity of Cytochrome P450 Monooxygenases by Protein Engineering; Conformational Changes in Cytochrome P450cam and the Effector Role of Putidaredoxin; Oxygen Reduction and Proton Translocation by Respiratory Cytochrome c Oxidase; Structure and Function of Membrane-bound Bacterial Nitric Oxide Reductases; Mechanisms of Nitric Oxide Sensing and Detoxification by Bacterial Hemoproteins

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