Overview

Dihydropyrimidinones as Potent Anticancer Agents gives readers a unique update on scientific knowledge, accomplishments and recent advances in the medicinal chemistry of dihydropyrimidinones in cancer treatment. Dihydropyrimidinones are known to be active scaffold and have been reported to show some exceptional results with regards to malignancies. With ever increasing knowledge and information about synthesis, pharmacology and other aspects of dihydropyrimidinones, there is need to document such information in one place. Since the field of medicinal chemistry is dynamic, with new emerging trends, it provides readily available updated information on chemistry and pharmacology aspects of dihydropyrimidinones in cancer. This book covers everything about dihydropyrimidinones from synthesis, derivatives, mode of action and potential therapeutic targets. It will also provide insights about the clinical trials and way forward in cancer research of dihydropyrimidinones.

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9780443190940

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Mashooq Ahmad Bhat (Ph.D.) is a faculty member and Professor of Pharmaceutical chemistry at College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. He holds a doctorate in Pharmaceutical Chemistry from Jamia Hamdard, New Delhi, India. Dr. Bhat has more than 18 years of research and teaching experience in the field of Pharmaceutical and Medicinal Chemistry. He is the recipient of several national and international fellowships and awards. He has published more than 90 research papers in peer-reviewed, international journals of Medicinal Chemistry. He has been granted 07 patens from United states patents office. He is also an expert reviewer of various international journals and funding organizations. Currently, Dr. Bhat is engaged in studying the breast cancer especially triple negative breast cancer and its possible treatment through drug design and synthesis of small molecules. Muneeb U Rehman (Ph.D.) is a Faculty member at College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. He holds a doctorate in Toxicology (specialization in cancer biology and natural product research) from Jamia Hamdard, New Delhi, India. Dr. Rehman has more than 10 years of research and teaching experience in the field of toxicology, cancer biology, natural product pharmacology and pharmacogenomics. He is the recipient of several national and international fellowships and awards. He has published more than 100 research papers in peer-reviewed, international journals, and has 5 edited books and 30 book chapters. Dr. Rehman is on the editorial boards and is a reviewer of several high-impact, international scientific journals. He is also a life member of various international societies and organizations. Currently, Dr. Rehman is engaged in studying the molecular mechanisms of cancer prevention by natural products and the role of pharmacogenomics and toxicogenomics in evaluating the effectiveness and safety of drugs. Amita Verma (Ph.D.) is a Principal Investigator, Bioorganic and Medicinal Chemistry Research Laboratory and Professor, Department of Pharmaceutical Sciences, Shalom Institute of Health and Allied Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, India. She has more than 15 years’ experience in teaching and research. Her area of research is to develop newer therapeutics against cancer, diabetes and other disorders by synthesizing compounds and isolating natural products from medicinal plants. She is also developing nanotherapeutics by using natural products. She has authored more than 100 publications.

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