Overview

This review examines the effectiveness of tissue autofluorescence using VELscope in detecting oral potentially malignant disorders. It compares this method with the standard approach of histopathological examination and other diagnostic tools. The review highlights that VELscope is a valuable, non-invasive aid that can identify abnormal tissue changes through fluorescence patterns. However, its diagnostic accuracy varies, with some instances of false positives and negatives reported. Because of these limitations, VELscope is recommended to be used alongside clinical examination and biopsy rather than as a standalone diagnostic method. Combining different diagnostic techniques enhances the detection of potentially malignant oral lesions. The review also suggests that further research is needed to improve the consistency and application of autofluorescence in clinical settings. Overall, tissue autofluorescence appears promising for early detection but requires careful interpretation.

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