Overview

The human immune system is a complex network of tissues and organs dispersed throughout the body. Immunology, as one of the most rapidly evolving fields in bio¬medical research, has to date covered the essential cellular and molecular events neces¬sary for immune responses to occur. However, it has paid relatively little attention to important developmental processes underlying the formation of the tissues themselves that carry out immune responses in humans and other mammalians. In contrast to the thymus and bone marrow that are the sole tissues for generating mature leukocytes for antigen recognition and han¬dling in humans and most mammalian species, the peripheral lymphoid tissues where adaptive immune responses are focused display broad tissue distribution and possess diverse archi¬tectural characteristics. These organs develop prior to the individual’s exposure to external antigens, and despite their similar functions, their varied appearances indicate a substantial complexity of tissue ontogeny. This volume presents a comprehensive overview of the developmental features of the major peripheral lymphoid organs, thus examining the connection between immunological functionality and structural characteristics utilizing a developmental approach, for an audience ranging from undergraduate students to senior researchers in immunology, histology and clinical medicine.

Full Product Details

Author:   Peter Balogh ,  Peter Balogh
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   2011 ed.
Dimensions:   Width: 15.50cm , Height: 1.50cm , Length: 23.50cm
Weight:   0.488kg
ISBN:  

9783642144288

ISBN 10:   3642144284
Pages:   177
Publication Date:   05 November 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Introduction: Evolution of peripheral lymphoid organs Common themes in lymphoid organ development Cellular partners in the embryonic induction of lymphoid territories: origins and transcriptional regulation Lymphotoxin/TNF and related molecules as morphogenic factors NF-kB signaling and lymphoid organ Homeostatic chemokines, cytokines and their receptors in peripheral lymphoid organ development Development of lymph nodes in humans and rodents Cellular and molecular determinants of lymphatic system development: Programmed and inflammation-induced differentiation Development of lymph nodes in humans and mice Development of lymph node circulation and homing mechanism 4Programmed and nascent gut-associated organized lymphoid tissues. Development of Peyer's patches Cryptopatches and Isolated Lymphoid Follicles: Aspects of development, homeostasis and function Single complexity: the spleen Developmental and structural characteristics of the spleen in humans and rodents Formation and maintenance of different lymphoid territories in spleen Age-associated decline in peripheral lymphoid organ functions

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