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Author:   Michael S. Wolfe (Professor of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Dimensions:   Width: 19.10cm , Height: 2.80cm , Length: 23.50cm
Weight:   1.520kg
ISBN:  

9780128021736

ISBN 10:   012802173
Pages:   676
Publication Date:   16 June 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. The Complex Pathways to Mechanism-Based Therapeutics in Alzheimer’s Disease 2. The Genetic Basis of Alzheimer's Disease 3. B-Secretase Inhibition 4. Y-Secretase Inhibitors: from Chemical Probes to Drug Development 5. Therapeutic Targeting of AB42 6. Modulators of Amyloid B-Protein (AB) Self-Assembly 7. Anti-Amyloid-B Immunotherapy for Alzheimer’s Disease 8. Targeting AB Receptors to Modify Alzheimer’s Disease Progression 9. Blood-Brain Barrier Transport of Alzheimer’s Amyloid B-Peptide 10. Alzheimer’s Disease Therapeutics Targeting Apolipoprotein E 11. Microtubule Stabilization 12. Tau Phosphorylation as a Therapeutic Target in Alzheimer's Disease 13. Stimulation of Tau Degradation 14. Passive Immunotherapy for Tau Pathology 15. Inhibition of Tau Aggregation as a Basis for Treatment and Prevention of Alzheimer’s Disease 16. Neuroprotective Strategies for Alzheimer’s Disease Prevention and Therapy 17. Symptomatic Cognitive Enhancing Agents 18. Tackling Alzheimer's Disease by Targeting Oxidative Stress and Mitochondria 19. Preclinical and Clinical Issues in Alzheimer Drug Development 20. Molecular Imaging in Alzheimer Clinical Trials 21. Fluid Biomarkers and Diagnostics 22. Non-Pharmacologic Activity Interventions to Prevent Alzheimer’s Disease 23. Prospects and Challenges for Alzheimer Therapeutics

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Author Information

Michael S. Wolfe is the Mathias P. Mertes Professor of Medicinal Chemistry at the University of Kansas. He received his B.S. in chemistry in 1984 from the Philadelphia College of Pharmacy and Science and Ph.D. in medicinal chemistry in 1990 from the University of Kansas. After postdoctoral stints at the University of Kansas (medicinal chemistry) and the NIH (cell biology), he joined the faculty of the University of Tennessee in Memphis in 1994. In 1999, he joined the faculty at Brigham and Women’s Hospital and Harvard Medical School in Boston, becoming Professor of Neurology in 2008. Prof. Wolfe’s work has focused on understanding the molecular basis of Alzheimer’s disease and related disorders, and identifying effective approaches for pharmacological intervention. Awards for his work include the Sato Memorial International Award in bioorganic and medicinal chemistry from the Pharmaceutical Society of Japan (2003), the MetLife Award for Biomedical Research (2008), a Zenith Fellows Award from the Alzheimer’s Association (2008), and the Potamkin Prize from the American Academy of Neurology (2009).

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