Overview

A collection of essays, based on research exploring ways in which the inhibition of the action of particular enzymes in the body can produce a desired therapeutic effect. The book contains accounts of the major target enzymes and their inhibitors which are currently the focus of research. The introductory chapters describe the underlying physical and chemical processes of enzyme inhibition and the general principles of inhibitor design using the many sophisticated and computer-based techniques that are now available. Subsequent chapters discuss in detail the wide range of individual target enzymes and inhibitors which are either in clinical use or are under study, emphasizing the factors which affect their usefulness in the clinical context - bioavailability, pharmaco kinetics and side-effects.

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9780192615374

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