Dermal Drug Selection and Development: An Industrial Perspective

Author:   Lionel Trottet ,  Howard Maibach
Publisher:   Springer International Publishing AG
Edition:   1st ed. 2017
ISBN:  

9783319595030


Pages:   148
Publication Date:   16 August 2017
Format:   Hardback
Availability:   Manufactured on demand   Availability explained
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Dermal Drug Selection and Development: An Industrial Perspective


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Author:   Lionel Trottet ,  Howard Maibach
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   1st ed. 2017
Weight:   3.731kg
ISBN:  

9783319595030


ISBN 10:   3319595032
Pages:   148
Publication Date:   16 August 2017
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Introduction.- Choosing the topical drug candidate.- Key factors affecting the efficacy of a topical drug candidate.- Topical vs. Oral/systemic Drug discovery.- Assessing drug concentration in skin.- Assessing Topical efficacy.- Assessing the therapeutic index.- Topical vehicle selection.- Topical drug development strategies.- Topical drug candidate selection criteria and cascade.- Selecting a dermal drug candidate.- Conclusions and perspectives.

Reviews

This book provides some valuable insights into the challenges related to the design and development of dermatopharmaceuticals. As such, this book is expected to be well received by the scientific community involved in this kind of research. ... this book should serve as a reference for anyone interested in developing dermatopharmaceuticals. ... Written by an expert in drug delivery, this book provides an overview of challenges the industry faces in selecting and developing a dermal product. (Rahmat M. Talukder, Doody's Book Reviews, September, 2017)


Author Information

Lionel Trottet, PhD is a DMPK Unit Manager, Drug Discovery chez Oncodesign in France. He has 20 years of expertise in Dermatology (dermal drug discovery, pharmacokinetics, PK/PD and formulation), 18 years of experience in general pharmacokinetics, drug metabolism and PK/PD, 13 years of experience as a DMPK representative in Drug Discovery projects, and 8 years of experience as a DMPK manager. Howard Maibach, MD is an expert in contact and occupational dermatitis and sees patients at the Environmental Dermatosis Clinic, which is part of the Dermatology Clinic at University of California, San Francisco (UCSF). His specialty is dermatotoxicology, or skin exposure toxicity; allergies and skin disorders; and dermatopharmacology or the study of medications for skin disorders. Dr. Maibach has been on the editorial board of more than 30 scientific journals and is a member of 19 professional societies including the American Academy of Dermatology, San Francisco Dermatological Society and the Internal Commission on Occupation Health. He is a professor in the Department of Dermatology at UCSF.

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