Overview

Defects in Secretion of Cystic Fibrosis presents an overview on current research from leading experts in North America and Europe. This update on cystic fibrosis provides in depth original work as well as review material on many of the relevant physiological and molecular topics in the field. Subjects covered include the interplay of the various epithelial ion channels, the underlying intracellular signal transduction, mucus secretion, and novel approaches to develop drugs against cystic fibrosis. This book brings together physicians, physiologists, and other scientists involved in basic research, from molecular biology to drug design and introduces novel investigative and therapeutic aspects of secretion disorders relevant in cystic fibrosis and related diseases. This book will be of interest to Molecular biologists, physiologists, scientists working in pharmaceutical research and drug developement, physicians and researchers in Cystic fibrosis and related diseases.

Full Product Details

Author:   Carsten Schultz
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2005 ed.
Dimensions:   Width: 17.00cm , Height: 1.10cm , Length: 24.40cm
Weight:   0.454kg
ISBN:  

9781461498391

ISBN 10:   1461498392
Pages:   179
Publication Date:   26 November 2014
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Outside Neurons/Inside Epithelia: Novel Activation of CFTR Cl? and HCO3 ? Conductances.- Role of CFTR and Other Ion Channels in Cystic Fibrosis.- Ion Channels in the Apical Membrane: Role of Electrical Coupling on Transepithelial Transport.- Ion Channels in Secretory Granules of the Pancreas: Molecular Identification and Their Role in Regulated Secretion.- Epithelial Transport and Intracellular Trafficking: Physiology and Pathophysiology.- Kinases, Cell Volume, and the Regulation of Chloride Channels.- The CLCAs: Proteins with Ion Channel, Cell Adhesion and Tumor Suppressor Functions.- Is Intervention in Inositol Phosphate Signaling a Useful Therapeutic Option for Cystic Fibrosis?.- An Inositol Phosphate Analog, INO-4995, Normalizes Electrophysiology in CF Airway Epithelia.- Vitamin C and Flavonoids Potentiate CFTR Cl Transport in Human Airway Epithelia.- Airway Glycoconjugates Secreted in Cystic Fibrosis and Severe Chronic Airway Inflammation Relationship with Pseudomonas aeruginosa.- Biosynthesis and Secretion of Mucins, Especially the MUC2 Mucin, in Relation to Cystic Fibrosis.

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