Decoding the Antibody Repertoire: High Throughput Sequencing of Multiple Transcripts from Single B Cells
Author:   Brandon DeKosky
Publisher:   Springer International Publishing AG
Edition:   1st ed. 2017
ISBN:  

9783319585178


Pages:   87
Publication Date:   08 June 2017
Format:   Hardback
Availability:   Manufactured on demand   Availability explained
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Decoding the Antibody Repertoire: High Throughput Sequencing of Multiple Transcripts from Single B Cells


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Author:   Brandon DeKosky
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   1st ed. 2017
Weight:   0.454kg
ISBN:  

9783319585178


ISBN 10:   3319585177
Pages:   87
Publication Date:   08 June 2017
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Background.- High-throughput Sequencing of the Paired Human Immunoglobulin Heavy and Light Chain Repertoire.- In-Depth Determination and Analysis of the Human Paired Heavy and Light Chain Antibody Repertoire.- Paired VH:VL Analysis of Naïve B Cell Repertoires and Comparison to Antigen-Experienced B Cell Repertoires in Healthy Human Donors.- Conclusions and Future Perspectives.- Appendices.

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Author Information

Brandon DeKosky is an assistant professor at the Departments of Pharmaceutical Chemistry, Chemical & Petroleum Engineering, and the Kansas Vaccine Institute at the University of Kansas.  Dr. DeKosky attained his Ph.D. in the lab of George Georgiou at the University of Texas at Austin where he developed new technologies for sequencing complete antibody variable regions from single B cells.  Dr. DeKosky performed postdoctoral studies in the lab of John Mascola at the NIAID Vaccine Research Center, applying high-throughput technologies to accelerate public health vaccine development.  His lab at KU seeks to leverage high-throughput platforms to understand the features of adaptive immune protection and develop novel strategies to combat human diseases.

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