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Author:   Vladimir N Uversky (Department of Molecular Medicine and USF Health Byrd Alzheimer’s Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, United States)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Weight:   0.800kg
ISBN:  

9780128168516

ISBN 10:   012816851
Pages:   424
Publication Date:   12 September 2019
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

1. Protein intrinsic disorder and structure-function continuum Vladimir N. Uversky 2. Intrinsic disorder associated with 14-3-3 proteins and their partners Nikolai N. Sluchanko and Diego M. Bustos 3. Intrinsically disordered proteins and phenotypic switching: Implications in cancer Vivek Kulkarni and Prakash Kulkarni 4. Translational diffusion of unfolded and intrinsically disordered proteins Irina V. Nesmelova, Daria L. Melnikova, Venkatesh Ranjan and Vladimir D. Skirda 5. Intrinsically disordered proteins in the formation of functional amyloids from bacteria to humans Anamika Avni, Hema M. Swasthi, Anupa Majumdar and Samrat Mukhopadhyay 6. Intrinsically disordered proteins in various hypotheses on the pathogenesis of Alzheimer's and Parkinson's diseases Orkid Coskuner and Vladimir N. Uversky 7. Shear-induced amyloid formation of IDPS in the brain Conrad N. Trumbore 8. Role of intrinsic disorder in muscle sarcomeres Dmitri Tolkatchev, Garry E. Smith Jr. and Alla S. Kostyukova 9. Computational prediction of functions of intrinsically disordered regions Akila Katuwawala, Sina Ghadermarzi and Lukasz Kurgan 10. The dark proteome of cancer: Intrinsic disorderedness and functionality of HIF-1a along with its interacting proteins Neha Garg, Prateek Kumar, Kundlik Gadhave and Rajanish Giri

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Prof. Vladimir N. Uversky, PhD, DSc, FRSB, FRSC, F.A.I.M.B.E., Professor at the Department of Molecular Medicine, Morsani College of Medicine, University of South Florida (USF), is a pioneer in the field of protein intrinsic disorder. He has made a number of groundbreaking contributions in the field of protein folding, misfolding, and intrinsic disorder. He obtained his academic degrees from Moscow Institute of Physics and Technology (Ph.D., in 1991) and from the Institute of Experimental and Theoretical Biophysics, Russian Academy of Sciences (D.Sc., in 1998). He spent his early career working mostly on protein folding at the Institute of Protein Research and the Institute for Biological Instrumentation (Russia). In 1998, moved to the University of California Santa Cruz. In 2004, joined the Indiana University-Purdue University Indianapolis as a Senior Research Professor. Since 2010, Professor Uversky is with USF, where he works on various aspects of protein intrinsic disorder phenomenon and on analysis of protein folding and misfolding processes. Prof. Uversky has authored over 1250 scientific publications and edited several books and book series on protein structure, function, folding, misfolding, and intrinsic disorder. He is also serving as an editor in a number of scientific journals. He was a co-founder of the Intrinsically Disordered Proteins Subgroup at the Biophysical Society and the Intrinsically Disordered Proteins Gordon Research Conference. Prof. Uversky collaborated with more than 12,500 colleagues from more than 2,750 research organizations in 89 countries/territories.

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