Overview

This book synthesizes the information on the role of cytokines in autoimmunity. It develops a clear understanding of the cytokins and chemokines involved in the pathogenesis of autoimmune disease and discusses the role of various cytokine antagonists in the inhibition of autoimmunity. Cytokines are soluble molecules produced by immune cells by which the immune system communicates with other cell types within or outside the immune system. By virtue of this function, cytokines serve to enhance or inhibit the functions of other cell types. It is increasingly clear that cytokines play a central role in the induction and regulation of autoimmune disease. Section I ( Cytokines: Induction, transcription and differentiation) deals with the basic mechanisms of induction and regulation of pro-inflammatory and anti-inflammatory cytokines, especially the effect of strength of TcR and costimulatory signals in the induction of various cytokines. Section II (Cytokines: role in specific autoimmune disease) will deal with the role of Cytokines in specific autoimmune diseases like EAE/MS; Type 1 diabetes, Rheumatoid Arthritis and Myasthenia gravis. Section III (Cytokines: induction and regulation of autoimmunity) synthesizes the information based upon the first two sections and thus provides a consensus on the role of cytokines in the induction and regulation of autoimmunity.

Full Product Details

Author:   Vijay K. Kuchroo ,  Nora Sarvetnick ,  David A. Hafler ,  Lindsay B. Nicholson
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2002 ed.
Dimensions:   Width: 15.20cm , Height: 2.80cm , Length: 22.90cm
Weight:   1.800kg
ISBN:  

9780896038561

ISBN 10:   0896038564
Pages:   422
Publication Date:   09 November 2001
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

I: Cytokines: Induction and Regulation.- 1 Transcriptional Regulation of Cytokine Gene Expression in Th Subsets.- 2 Chromatin Remodeling and Transcriptional Regulation of Cytokine Gene Expression in T Cells.- 3 Variant Ligands, Altered T Cell Receptor Signaling, Hierarchial Response Thresholds, and CD4+ Effector Responses.- 4 The Role of Costimulation in T Cell Differentiation.- 5 CD I d-Restricted NK T Cells and Autoimmunity.- 6 Role of T Cell Death and Cytokines in Autoimmunity.- 7 Role of Chemokines and Their Receptors in the Induction and Regulation of Autoimmune Disease.- II: Cytokines: Role in Specific Autoimmune Diseases.- 8 Cytokines and Resistance to Organ Specific Autoimmune Disease.- 9 The Role of Cytokines in Induction and Regulation of Autoimmune Uveitis.- 10 Pathogenic and Regulatory Cytokines in Experimental Autoimmune Encephalomyelitis.- 11 Role of Cytokines in Multiple Sclerosis and in Mucosal Tolerance.- 12 Cytokines and Human Type 1 Diabetes.- 13 Cytokines in Human Rheumatoid Arthritis and Murine Models.- 14 Systemic Lupus Erythematosus.- 15 Myasthenia Gravis.- III: Cytokines and Autoimmunity: A Synthesis.- 16 Cytokines in Autoimmune Disease.

Reviews

Authoritative and state-of-the-art, Cytokines and Autoimmune Disease highlights the enormous therapeutic potential of cytokine modulation in the treatment of autoimmune disease. -Immunology News

"""Authoritative and state-of-the-art, Cytokines and Autoimmune Disease highlights the enormous therapeutic potential of cytokine modulation in the treatment of autoimmune disease."" -Immunology News"

Authoritative and state-of-the-art, Cytokines and Autoimmune Disease highlights the enormous therapeutic potential of cytokine modulation in the treatment of autoimmune disease. - Immunology News

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