Overview

The world experts in the fields of human gamete cytogenetics and the etiology of aneuploidy discuss the latest research in this volume. The frequency and distribution of abnormalities in human oocytes and sperm are explored, as are the effects of maternal and paternal ages. Research on basic mechanisms causing aneuploidy, such as decreased meiotic recombination, defective meiotic checkpoints, skewed X-chromosome inactivation, and biological aging are elaborated. With the advent of in vitro fertilization and intracytoplasmic sperm injection, there has been an explosion of research on the association of infertility with chromosome abnormalities in gametes. These are explored both for individuals with somatic chromosome abnormalities and for infertile patients who have a normal karyotype but still produce gametes with an increased frequency of cytogenetic abnormalities. The most recent research on meiotic abnormalities in these infertile patients is included. Since humans have such a devastating load of numerical chromosome abnormalities, environmental and lifestyle issues are discussed and related to mammalian model systems. This up-to-date and comprehensive volume will be a resource for geneticists, cell biologists, infertility experts, reproductive scientists, obstetricians, andrologists, and staff of assisted reproductive clinics.

Full Product Details

Author:   R.H. Martin
Publisher:   S Karger AG
Imprint:   S Karger AG
Volume:   v. 111, No. 3-4
Dimensions:   Width: 21.00cm , Height: 1.00cm , Length: 28.00cm
Weight:   0.940kg
ISBN:  

9783805580069

ISBN 10:   3805580061
Pages:   216
Publication Date:   23 September 2005
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   In Print  
Limited stock is available. It will be ordered for you and shipped pending supplier's limited stock.

Table of Contents

Preface; Unraveling the secrets of sex cells: Martin RH; Frequency and Distribution of Cytogenetic Abnormalities in Human Germ Cells; Frequency and distribution of chromosome abnormalities in human oocytes: Kuliev A, Cieslak J, Verlinsky Y; Frequency and distribution of chromosome abnormalities in human spermatozoa: Templado C, Bosch M, Benet J; Effect of maternal age on the frequency of cytogenetic abnormalities in human oocytes: Pellestor F, Anahory T, Hamamah S; Effect of paternal age on the frequency of cytogenetic abnormalities in human spermatozoa: Buwe A, Guttenbach M, Schmid M; Research on Basic Mechanisms Causing Aneuploidy; Mechanisms of aneuploidy induction in human oogenesis and early embryogenesis: Delhanty JDA; Mechanisms of nondisjunction in human spermatogenesis: Martin RH; Effect of meiotic recombination on the production of aneuploid gametes in humans: Lamb NE, Sherman SL, Hassold TJ; Meiotic spindle checkpoints for assessment of aneuploid oocytes: Steuerwald N; The association of skewed X chromosome inactivation with aneuploidy in humans: Bretherick K, Gair J, Robinson WP; Biological aging and the etiology of aneuploidy: Warburton D; Analysis of Human Germ Cells in Individuals with Somatic Chromosome Abnormality; Segregation of chromosomes in sperm of reciprocal translocation carriers: a review: Benet J, Oliver-Bonet M, Cifuentes P, Templado C, Navarro J; Segregation of chromosomes in sperm of Robertsonian translocation carriers: Roux C, Tripogney C, Morel F, Joanne C, Fellmann F, Clavequin MC, Bresson JL; Sperm studies in heterozygote inversion carriers: a review: Anton E, Blanco J, Egozcue J, Vidal F; Analysis of chromosome segregation during preimplantation genetic diagnosis in both male and female translocation heterozygotes: Munne S; Infertility and Chromosome Abnormalities in Human Gametes; Somatic chromosomal abnormalities in infertile men and women: Mau-Holzmann UA; Meiotic abnormalities in infertile males: Egozcue J, Sarrate Z, Codina-Pascual M, Egozcue S, Oliver-Bonet M, Blanco J, Navarro J, Benet J, Vidal F; Male infertility in reciprocal translocation carriers: the sex body affair: Oliver-Bonet M, Ko E, Martin RH; Chromosome abnormalities in sperm from infertile men with normal somatic karyotypes: oligozoo-spermia: Miharu N; Chromosome abnormalities in sperm from infertile men with normal somatic karyotypes: teratozoo-spermia: Machev N, Gosset P, Viville S; Chromosome abnormalities in sperm from infertile men with normal somatic karyotypes: asthenozoo-spermia: Rives NMD; Chromosome abnormalities in spermatozoa of patients with azoospermia and normal somatic karyotype: Burrello N, Vicari E, Calogero AE; Environmental and Lifestyle Factors; Effect of lifestyle exposures on sperm aneuploidy: Robbins WA, Elashoff DA, Xun L, Jia J, Li N, Wu G, Wei F; Pesticides and the induction of aneuploidy in human sperm: Harkonen K; Mechanisms and chemical induction of aneuploidy in rodent germ cells: Mailhes JB, Marchetti F; Mouse genetic models for aneuploidy induction in germ cells: Eichenlaub-Ritter U; Author Index.

Reviews

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions