Overview

Section I: Human Genomics and Genetics Mi ning Databases for Cytochrome P450 Genes. Sequence Alignmen ts, Variabilities, and Vagaries. Human CYP Allele Database: Submission Criteria Procedures and Objectives. Fine-Scale Mapping of CYP Gene Clusters: An Example from Human CYP4 Family. Detection of Single Nucleotide Polymorphisms in CYP2B6 Gene. Genotyping Human Cytochrome P450 1B1 Variants. Geno typing Human CYP2A Variants. Section II: Structure and Mechanism Purification and Crys tallization of N-Terminally Truncated Forms of Microsomal Cytochrome P45 0 2C5. Molecular Replacement in P450 Crystal Structure Dete rminations. Optical Biosensor and Scanning Probe Microscopy Studies of Cytochrome P450 Interactions with Redox Partners and Phospho lipid Layers. Cryoradiolysis for the Study of P450 Reaction Intermediates. Analyzing Binding of N-Terminal Truncated, Microsomal Cytochrome P450s to Membranes. Sensitizer-Linked

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9780121822606

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PRAISE FOR THE SERIES The Methods in Enzymology series represents the gold-standard. - NEUROSCIENCE Incomparably useful. - ANALYTICAL BIOCHEMISTRY It is a true 'methods' series, including almost every detail from basic theory to sources of equipment and reagents, with timely documentation provided on each page. - BIO/TECHNOLOGY The series has been following the growing, changing and creation of new areas of science. It should be on the shelves of all libraries in the world as a whole collection. - CHEMISTRY IN INDUSTRY The appearance of another volume in that excellent series, Methods in Enzymology, is always a cause for appreciation for those who wish to successfully carry out a particular technique or prepare an enzyme or metabolic intermediate without the tiresome prospect of searching through unfamiliar literature and perhaps selecting an unproven method which is not easily reproduced. - AMERICAN SOCIETY OF MICROBIOLOGY NEWS If we had some way to find the work most often consulted in the laboratory, it could well be Colowick and Kaplan's multi-volume series Methods in Enzymology...a great work. - ENZYMOLOGIA A series that has established itself as a definitive reference for biochemists. - JOURNAL OF CHROMATOGRAPHY

PRAISE FOR THE SERIES The Methods in Enzymology series represents the gold-standard. - NEUROSCIENCE Incomparably useful. - ANALYTICAL BIOCHEMISTRY It is a true 'methods' series, including almost every detail from basic theory to sources of equipment and reagents, with timely documentation provided on each page. - BIO/TECHNOLOGY The series has been following the growing, changing and creation of new areas of science. It should be on the shelves of all libraries in the world as a whole collection. - CHEMISTRY IN INDUSTRY The appearance of another volume in that excellent series, Methods in Enzymology, is always a cause for appreciation for those who wish to successfully carry out a particular technique or prepare an enzyme or metabolic intermediate without the tiresome prospect of searching through unfamiliar literature and perhaps selecting an unproven method which is not easily reproduced. - AMERICAN SOCIETY OF MICROBIOLOGY NEWS If we had some way to find the work most often consulted in the laboratory, it could well be Colowick and Kaplan's multi-volume series Methods in Enzymology...a great work. - ENZYMOLOGIA A series that has established itself as a definitive reference for biochemists. - JOURNAL OF CHROMATOGRAPHY

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Edited by Eric F. Johnson, and Michael R. Waterman

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