Cyclin Dependent Kinase (CDK) Inhibitors

Author:   Peter K. Vogt ,  Stephen I. Reed
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Edition:   Softcover reprint of the original 1st ed. 1998
Volume:   227
ISBN:  

9783642719431


Pages:   169
Publication Date:   30 December 2011
Format:   Paperback
Availability:   Manufactured on demand   Availability explained
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Cyclin Dependent Kinase (CDK) Inhibitors


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Overview

More than 10 years ago, the discovery of cyclin-dependent ki nases (Cdks) ushered in a new era in the understanding of cell proliferation and its control. Not only were both of the known cell cycle transitions, from G 1 to S phase and G2 to M phase, found to be dependent on these protein kinases, but the reg ulatory assumption intrinsic to cyclin-dependent kinases, a stable inactive catalytic subunit (the Cdk) and an unstable requisite positive regulatory activating subunit (the cyclin), led to a simple model for cell cycle control. Modulation of cyclin accumulation, and thereby Cdk activation, was proposed to be the overarching principle governing the passage through cell cycle phases. An other reality to emerge from the discovery of Cdks was the ex ceptional degree of evolutionary conservation maintained in the machinery and organization of proliferation control. Not only were Cdks shown to be structurally conserved between yeast and man, but mammalian Cdks could substitute functionally for the endogenous enzymes in a yeast cell. The problem of cell cycle control was thought to have been virtually solved. The ensuing years have provided a much more complex view of cell cycle control and the role and regulation of Cdks. The uncritical enthusiasm with which many of the ideas were em braced has required tempering. For example, although Cdks appear to be highly conserved phylogenetically, cyclins are much less so.

Full Product Details

Author:   Peter K. Vogt ,  Stephen I. Reed
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1998
Volume:   227
Dimensions:   Width: 15.50cm , Height: 1.00cm , Length: 23.50cm
Weight:   0.295kg
ISBN:  

9783642719431


ISBN 10:   3642719430
Pages:   169
Publication Date:   30 December 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

List of Contents.- Cyclin-Dependent Kinase Inhibitors of Saccharomyces cerevisiae and Schizosaccharomyces pombe.- Inhibitors of the Cip/Kip Family.- The INK4 Family of CDK Inhibitors.- Role of Cyclin-Dependent Kinases and Their Inhibitors in Cellular Differentiation and Development.- Roles of Cyclin-Dependent Kinase Inhibitors: Lessons from Knockout Mice.- p21/p53, Cellular Growth Control and Genomic Integrity.- Cyclin-Dependent Kinase Inhibitors and Human Cancer.- Small-Molecule Inhibitors of Cyclin-Dependent Kinases: Molecular Tools and Potential Therapeutics.

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