Overview

Provides practical information on the clinical use of leading antifungal agents, addressing their comparative efficacy, safety and patient acceptance. The chemistry, mode of action and in vitro and in vivo experimental results of antifungal drugs are discussed.

Full Product Details

Author:   John Rippon (Safety Harbor, Florida, USA) ,  Robert A. Fromtling
Publisher:   Taylor & Francis Inc
Imprint:   Marcel Dekker Inc
Volume:   7
Dimensions:   Width: 21.60cm , Height: 2.90cm , Length: 27.90cm
Weight:   0.816kg
ISBN:  

9780824790554

ISBN 10:   0824790553
Pages:   488
Publication Date:   13 May 1993
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Out of Stock Indefinitely
Availability:   Awaiting stock  

Table of Contents

Introduction - antifungal therapy for cutaneous mycoses, John W. Rippon and Robert A. Fromtling; morpholines - discovery and chemistry of amorolfine, Hans Peter Isenring, preclinical data of amorolfine, Annemarie Polak and Peter George Hartman, the action of amorolfine - from molecule to cell, Peter George Hartman and Annemarie Polak, safety of amorolfine in healthy volunteers and patients, Michael Zaug and Gaetano Roncati, clinical efficacy of amorolfine, Michael Zaug, clinical experiences with amorolfine, Amalia del Palicio; allylamines - naftifine - in vitro and in vivo activities of naftifine, Hubert Mieth, biochemical mode of action of naftifine, Neil S. Ryder, clinical experience with naftifine, Matthias Brautigam and Gottfried Weidinger; terbinafine - the discovery and chemistry of terbinafine, Anton Stutz, biochemical mode of action of terbinafine, Neil S. Ryder, in vitro and in vivo activities of terbinafine, Hubert Mieth, clinical use of oral and topical terbinafine in the treatment of fungal diseases, V.V. Villars and T.C. Jones; fluconazole - the discovery of fluconazole, K. Richardson, chemistry and mode of action of fluconazole, C.A. Hitchcock and P.J. Whittle, in vitro and experimental in vivo activities of fluconazole against some fungi causing cutaneous mycoses, Peter F. Troke, safety of fluconazole, Ian H. Osterloh and Nigel D. Pluck, clinical efficacy of fluconazole in the treatment of cutaneous mycoses, Keith W. Brammer; itraconazole - itraconazole - preclinical data in vitro and in vivo in cutaneous and other superficial mycoses, Frank C. Odds and Jan Van Cutsem, discovery, chemistry, mode of action, and selectivity of itraconazole, H. Vanden Bossche et al, safety of itraconazole in animals and humans, Ann Lampo et al, clinical efficacy of itraconazole - focus on cutaneous infections, Geert Cauwenbergh, clinical experience with itraconazole, E.L. Svejgaard; compounds in development - the nikkomycins - an overview of nikkomycins - history, biochemistry, and applications, Hans Peter Fiedler et al, the use of nikkomycin Z singly and in combination with azoles for infections caused by Candida, Richard F. Hector, interactions between chitin and beta glucan synthesis inhibitors - a new approach to antifungal development for cutaneous infections, John R. Perfect; the pneumocandins - discovery, production process development, and isolation of pneumocandin B[0], Robert E. Schwartz et al, chemical and structure-activity studies of the echinocandin lipopeptides, Milton L. Hammond, biological activity of the pneumocandins, Ken Bartizal et al.

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