Overview

This book covers a wide spectrum of areas related to basic bone research. While bone remodeling, bone development, and osteoclast biology constitute the main contents, topics important to the understanding of bone metabolism and treatment of bone-related diseases are also intensively reviewed. Three chapters are dedicated to the classic topic of bone mechanics, which include a brief overview of the mechanostat hypothesis, a more detailed review on mechanotransduction and bone adaptation, and a chapter illustrating the basic principles of bone mechanical testing. New emerging fields such as skeletal stem cells, bone tissue engineering, phytoestrogens applications, and bone genetics study using mouse models, are also covered in detail. The book closes with a special chapter dedicated to state-of-the-art advances in bone biology research.Contents: International Chinese Hard Tissue Society — The Power that Connects the World of Science and Culture (D X Ji & W S S Jee) Integrated Bone Tissue Anatomy and Physiology (X-J Li & W S S Jee) Skeletal Stem Cells (M Connolly & G Li) Osteoclast Biology (X Feng & H Zhou) Intercellular Communication of Osteoblast and Osteoclast in Bone Diseases (J Xu et al.) Osteoclasts and Inflammatory Osteolysis (L Xing et al.) Endochrondral Bone Formation and Extracellular Matrix (Q Chen et al.) Bone Morphogenetic Proteins in Bone Formation and Development (X-J Qi et al.) Mechanical Testing for Bone Specimens (L Qin & M Zhang) Estrogens and Androgens on Bone Metabolism (A Kung & J Gu) Phytoestrogens and Bone Health: Mechanisms of Action (Z C Dang) Regulation of Bone Remodeling (D Chen et al.) TGFB in Chondrocyte Biology and Cartilage Pathology (T F Li et al.) Bone Health in Children and Adolescents (J M Lappe) The Mechanostat Hypothesis for Bones and Other Skeletal Organs (H M Frost) Mechanotransduction and Its Role in Bone Adaptation (Y Qin & C Rubin) Bio-Pathology of Bone Tumors (L Huang et al.) Bone Tissue Engineering (X Yang & R O C Oreffo) Bone Genetic Factors Determined Using Mouse Models (W Gu & Y Jiao) Recent Advances in Bone Biology Research (D Chen et al.) Readership: Scientists and researchers in the bone field; clinicians, especially endocrinologists, orthopedists, gynecologists and pediatricians; medical students; and students majoring in biomedical sciences (undergraduate and graduate).

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