Overview

Organ transplantation has revolutionized the treatment for end-stage organ failure. Immunosuppression is still a major approach currently used in the prevention and treatment of allograft rejection. Both editors Dr. Chen and Dr. Qian have been contributing to preclinical evaluation of immunosuppressants for more than 25 years in North America. Experts from the United States, Canada, the United Kingdom, China, Japan, Germany, Sweden, Hungary and Brazil contributed 23 chapters to this book, providing details of immunological basis in transplantation. They also describe six classes of immunosuppressive agents (calcineurin inhibitors, mTOR inhibitors, JAK-STAT inhibitors, antiproliferative agents, costimulation blockers and corticosteroids), as well as ischemia/reperfusion injury treated agents. Additionally, the new development of cell therapy in the induction of transplant tolerance is introduced. This book provides many important references for the research direction of novel immunosuppressants. Readers that will find this book useful include transplant physicians, surgeons, nurses, immunologists, pharmacologists, pharmacists, medical students, residents and trainees in transplantation.

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9781634828987

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Dr. Huifang Chen, currently holds Professor of Surgery at Universite de Montreal, Canada, graduated from Shanghai Medical College, Fudan University, M.D. (19641970), obtained M.Sc. (19781981) and Ph.D. (19811985) degrees from same university. After working in clinical urology and organ transplantation for 18 years in China, Dr. Chen has undertaken organ transplantation research and teaching in North America since 1988, in collaboration with major pharmaceutical companies, e. g., Astellas Japan, Roche USA, Novartis Switzerland, Wyeth-Ayerst (Pfizer) USA to evaluate new drugs in preclinical studies. Dr. Chen is a visiting professor of three medical schools in China (Fudan University, Soochow University, and Sun Yat-Sen University). He has supervised 55 MSc, PhD, graduate students, post-doctoral trainees, residents, and visiting professors in his laboratory. He is Board Reviewer of 4 medical journals, member of 6 scientific associations, President of International Society for Experimental Microsurgery (20122014). Dr. Chen has published 140 articles and 235 abstracts in medical journals. He is the Chief Editor of the book entitled: Experimental Organ Transplantation published in 2013 by Nova Science Publishers, Inc., New York.

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