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Cryptic Enzymes and Moonlighting

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Author:   Helen Irving, PhD (Professor in Biomedical Sciences, La Trobe Institute for Molecular Sciences (LIMS), Melbourne, Australia) ,  Chris Gehring (Professor, Department of Chemistry, Biology and Biotechnology, Università degli Studi di Perugia UNIPG, Italy) ,  Aloysius Wong, PhD (Assistant Professor, Wenzhou-Kean University, Wenzhou, China)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Weight:   0.810kg
ISBN:  

9780443157196

ISBN 10:   0443157197
Pages:   390
Publication Date:   18 June 2025
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

1. Introduction and overview of moonlighting enzymes in signal cascades Constance Jeffery 2. Extracellular vesicles enabling moonlighting proteins Pamali Fonseka, Sriram Gummadi, Akbar Lulu Marzan, Sai Vara Prasad Chitti, Suresh Mathivanan 3. Eukaryotic moonlighting proteins that assist microbial infections Mohd Akif 4. Moonlighting proteins in neurobiology signaling mediated by G protein coupled receptors (GPCRs). Adrián Martínez Cortés, Mariana Mirchandani-Duque, Aracelis Hernández-García, Dasiel Oscar Borroto Escuela, Adam Danielson, Esther Berrocoso, Malak Choucri, Jose Laffita, Kjell Fuxe 5. Metabolic enzymes co-opted in oncogenic signaling Bailey Nance, Brian Keith, Marie Simon 6. Metabolic enzymes moonlighting as RNA binding and regulatory proteins Constance Jeffery 7. Cryptic enzymes as fine tuners of signaling cascades Aloysius Wong, Helen Irving, Christoph Gehring 8. Dual function plant cryptic nucleotide cyclases Marcella Bracale, Maria Concetta de Pinto, Cecilia Lasorella, Eleonora David, Stefania Fortunato, Candida Vannini, Guido Domingo 9. Crypto adenylate cyclases coming of age Adriana Szmidt-Jaworska, Brygida Swiezawska 10. Crypto adenylate cyclases moonlighting with phosphodiesterases in complex proteins Mateusz Kwiatkowski, Krzysztof Jaworski 11. Gas sensing H-NOX hemo proteins in plants and beyond Chuyun Bi, Christoph Gehring, Aloysius Wong 12. Modulating the immune response via cryptic enzymes Trang Nguyen, Helen Irving, Cassandra Cianciarulo, Joseph Tucci, Ilona Turek 13. Cryptic moonlighting enzymes enable crosstalk with other signaling molecules Julia Davies 14. Identifying hidden moonlighting proteins and protein regions Daisuke Kihara 15. Computational approaches and bioinformatic tools for the identification of cryptic enzymes Shiyu Jiang, Aloysius Wong, Chuyun Bi 16. Establishing cryptic enzyme interactomes Ilona Turek, Santosh Ramabhadra Rao Tata, Helen Irving 17. Assessing contributions of moonlighting proteins to signal cascades Jiri Friml, Linlin Qi 18. Uncovering moonlighting proteins in cell organelles Anushka Date, Helen Irving, Santosh Ramabhadra Rao Tata

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Author Information

Helen Irving is a Professor in Biomedical Sciences and is a member of the La Trobe Institute for Molecular Sciences (LIMS) in Melbourne, Australia. Helen's current research centers on understanding inflammatory signals at the molecular level to develop new and improved approaches to managing inflammatory conditions. Helen obtained her PhD in Biochemistry from The University of Melbourne and conducted post-doctoral work at Vanderbilt University (USA) and The University of Kentucky (USA) before returning to Australia to take up an ARC Post-Doctoral Fellowship at La Trobe University. For most of her career, she has been a teaching and research academic based at the Faculty of Pharmacy and Pharmaceutical Sciences at Monash University. Helen moved to the La Trobe Institute for Molecular Sciences (LIMS) at La Trobe University in 2017. Dr. Chris Gehring is based at the Università degli Studi di Perugia UNIPG, in the Department of Chemistry, Biology & Biotechnology. His research focuses on plant signalling peptides, with a focus on various peptide signalling molecules in development, defense, and homeostasis. He has published widely in such peer reviewed journals as Nature, Molecular Plant, Trends in Genetics, and the Journal of Biological Chemistry. Dr. Aloysius Wong earned a PhD in Bioscience from King Abdullah University of Science and Technology (KAUST), Saudi Arabia, as well as a MA in Biotechnology from the University of Cambridge, UK. In past positions, he has served as a post-doctoral researcher at the French National Centre for Scientific Research. Dr. Wong seeks to understand, from a molecular perspective, how plants, despite being sessile and immobile, can efficiently perceive environmental (biotic and abiotic) signals and launch short- and long-term biological responses that enable them to survive in environments considered hostile to plants. Dr. Wong has published widely in peer reviewed journals.

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