Overview

Introduction to Crucial Pharmacology Trends (CPT), Volume 5 Editors: Dr. Shiva Murthy N, Dr. Melvin George, Dr. Phulen Sarma, Dr. Mukundam Borah, and Dr. Bikash Medhi, CPT (Vol. 5) continues the series' objective of providing a concise, concept-oriented, and examination-focused resource for PGs in pharmacology and young researchers. This volume integrates core pharmacological principles with emerging scientific, clinical, and technological advances shaping modern therapeutics. Section I: Molecular and Mechanistic Frontiers in Pharmacology explores the molecular basis of drug action, revisiting pharmacodynamic/kinetic concepts such as receptor and non-receptor mechanisms, cytochrome P450 enzymes, cytokine receptors, nuclear receptors, and topics such as sanctuary compartments, vectorial transport, neuropeptides in the gut-brain axis, therapeutic enzymes, and drugs targeting apoptosis and angiogenesis. Section II: Translational and Experimental Pharmacology connects laboratory research with clinical practice, addressing CRFs design, PK compartment models, drug-induced toxicity, IDDSs, and modern clinical trial approaches. Section III: Clinical, Ethical, and Emerging Trends in Pharmacology discusses rational prescribing, antimicrobial stewardship, pharmacotherapy in organ failure, drug price regulation, AI in drug discovery, ethical AI frameworks, and therapeutic challenges related to rare diseases and orphan drugs.

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