Overview
Extracellular MRI and X-ray contrast agents are characterized by their phar- cokinetic behaviour.After intravascular injection their plasma-level time curve is characeterized by two phases. The agents are rapidly distributed between plasma and interstitial spaces followed by renal elimination with a terminal half-live of approximatly 1–2 hours. They are excreted via the kidneys in unchanged form by glomerular filtration. Extracellular water-soluble contrast agents to be applied for X-ray imaging were introduced into clinical practice in 1923. Since that time they have proved to be most valuable tools in diagnostics.They contain iodine as the element of choice with a sufficiently high atomic weight difference to organic tissue. As positive contrast agents their attenuation of radiation is higher compared with the attenuation of the surrounding tissue. By this contrast enhancement X-ray diagnostics could be improved dramatically. In 2,4,6-triiodobenzoic acid derivatives iodine is firmly bound. Nowadays diamides of the 2,4,6-triiodo-5-acylamino-isophthalic acid like iopromide (Ultravist, Fig. 1) are used as non-ionic (neutral) X-ray contrast agents in most cases [1].
Full Product Details
Author: Werner Krause
Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition: Softcover reprint of hardcover 1st ed. 2002
Volume: 221
Weight: 0.445kg
ISBN: 9783642075964
ISBN 10: 3642075967
Pages: 249
Publication Date: 15 December 2010
Audience:
Professional and scholarly
,
Professional & Vocational
Format: Paperback
Publisher's Status: Active
Availability: Out of stock
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.
Reviews
The text of all chapters is organized in a logical and capacious manner. Although the book is an assemblage of parts written by different authors, the overall uniformity of the work is commendable and the readability is good.The book educates us about a fascinating, but also difficult, area. It is one of the few books that shows the greatest assortment and chemical details about contrasts agents of MRI.- EUROPEAN RADIOLOGY
The text of all chapters is organized in a logical and capacious manner. Although the book is an assemblage of parts written by different authors, the overall uniformity of the work is commendable and the readability is good. The book educates us about a fascinating, but also difficult, area. It is one of the few books that shows the greatest assortment and chemical details about contrasts agents of MRI. - EUROPEAN RADIOLOGY
