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Author:   Gabriele Baumann
Publisher:   Springer Verlag GmbH
Imprint:   Springer Verlag GmbH
Edition:   2011 ed.
Dimensions:   Width: 15.50cm , Height: 0.90cm , Length: 23.50cm
Weight:   0.261kg
ISBN:  

9783709117422

ISBN 10:   3709117429
Pages:   149
Publication Date:   30 October 2014
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

1 Long known, long ignored – a brief history of cytomegalovirus research 1.1 Beginnings: 1881–1914 1.2 Between the wars: 1914–1930 1.3 From 1930 to 1960 1.4 From 1960 to the present References  2 Virus-host interaction for defence and transmission 2.1 The virus 2.2 The host 2.2.1 Cell types involved in replication and distribution 2.2.2 The immune system – strengths and weakness 2.2.3 The placenta – a barrier? 2.2.4 Cytomegalovirus – placenta – fetus: a slippery slope between defence and transmission References  3 Epidemiology – the influence of socioeconomic differences 3.1 Infant mortality as a social mirror 3.2 One effect – many causes 3.2.1 Maternal aetiology 3.2.2 Foetal aetiology 3.2.3 Placental aetiology 3.3 Epidemiology of congenital CMV infection 3.3.1 Congenital CMV and virus strains References  4 Prospects and obstacles of diagnosis 4.1 Screening for congenital CMV infection 4.1.1 Screening of the mother 4.1.2 Screening of the newborn 4.2 Diagnosis of congenital CMV infection 4.2.1 Prenatal diagnosis 4.2.2 Neonatal diagnosis References  5 Clinical outcome: acute symptoms and sleeping hazards Thorsten W. Orlikowsky 5.1 Relevance of connatal CMV infection for the paediatrician and neonatologist 5.2 The tip of the iceberg 5.3 Lucky chance by neonatal immune response 5.4 Features of symptomatic CMV infection 5.5 Timing of infection 5.6 Symptoms of the central nervous system in detail 5.6.1 Microcephaly5.6.2 Ocular defects 5.6.3 Hearing loss 5.6.4 Mental and psychomotor retardation 5.6.5 Seizures 5.7 Unspecific symptoms in detail 5.7.1 Temperature instability 5.7.2 Perfusion and rash 5.7.3 Lung 5.7.4 Liver 5.7.5 Jaundice 5.7.6 Spleen 5.7.7 Platelet system 5.7.8 Anaemia 5.7.9 Gastrointestinal tract 5.8 Asymptomatic infection 5.9 Differential diagnosis References  6 Prevention and therapy – more than trial and error 6.1 Antivirals 6.1.1 Treatment of pregnant women 6.1.2 Treatment of neonates 6.2 Passive immunisation 6.3 Active immunisation (vaccination) References 7 How to save money: congenital CMV infection and the economy Evelyn Walter, Christine Brennig, Vera Schollbauer 7.1 Introduction 7.2 Methodology 7.2.1 Incidence-based approach 7.2.2 Cost calculation 7.2.3 Cost of sequelae 7.3 Cost of illness in Germany 7.3.1 Total societal costs 7.3.2 Sensitivity analysis 7.3.3 Impact through prevention 7.4 Discussion References Index List of contributors

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Author Information

CV ao. Univ. Prof. Prim. Dr. med. Gabriele Halwachs-Baumann, MSc, MBABorn: 21. 02. 1962, Gmunden, AustriaAcademic studies:1981 – 1990 Medical study at the Karl-Franzens-University in Graz, Austria19. 12. 1990 Medical degreePostgraduate studies:2005 – 2006 University Course Health Services Management (Master of Science, MSc) at the Donau University Krems, Austria2006 – 2007 University Study Health Care Management (Master of Business Administration, MBA), at the University of Economics and Business, Vienna, AustriaAcademic career:1991 – 1996 Assistant at the Department of Internal Medicine, Division for Laboratory Medicine, University Hospital Graz1996 – 1997 Research period at the University of Tübingen, Germany, Department of Virology15.02.1998 Specialist for Laboratory Medicine27.05.1998 University lecturer for Laboratory Medicine01.10.1998 ao. University Professor for Laboratory Medicine2001 – 2006 Head of the Division for Laboratory Medicine at the University Clinics for Surgery, University Hospital Graz2006 – pres. Head of the Department (Primaria) for Laboratory Medicine at the Hospital Steyr

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