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"Volume 542 of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This new volume covers research methods providing a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic changes when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as ""yet another"" general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm rather represent a molecular signature that intimately accompanies, and hence cannot be severed from, all facets of malignant transformation."

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9780124166189

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Lorenzo Galluzzi received his Ph.D. in 2008 from the University of Paris Sud/Paris XI, France, and now works as a Research Manager in the laboratory of Guido Kroemer. He is particularly fascinated by several aspects of mitochondrial cell death, oncometabolism and tumor immunology. Guido Kroemer received his M.D. in 1985 from the University of Innsbruck, Austria, and his Ph.D. in 1992 from the Autonomous University of Madrid, Spain. He now works as a Research Director at the French Medical Research Council (INSERM) in Villejuif, France, as a Full Professor at the University of Paris Descartes, France, and as a hospital practitioner at the Hopital Europeen George-Pompidou, Paris, France. His research interests encompass mitochondrial cell death, autophagy and the immune response to dying cancer cells.

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