Conceptual Background and Bioenergetic/Mitochondrial Aspects of Oncometabolism

Author:   Lorenzo Galluzzi (Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USA) ,  Guido Kroemer (INSERM Cordeliers Research Cancer Paris; Hopital Europeen Georges Pompidou; Universite Paris Descartes, France)
Publisher:   Elsevier Science Publishing Co Inc
Volume:   542
ISBN:  

9780124166189


Pages:   536
Publication Date:   29 May 2014
Format:   Hardback
Availability:   Manufactured on demand   Availability explained
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Conceptual Background and Bioenergetic/Mitochondrial Aspects of Oncometabolism


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"Volume 542 of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This new volume covers research methods providing a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic changes when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as ""yet another"" general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm rather represent a molecular signature that intimately accompanies, and hence cannot be severed from, all facets of malignant transformation."

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Author:   Lorenzo Galluzzi (Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USA) ,  Guido Kroemer (INSERM Cordeliers Research Cancer Paris; Hopital Europeen Georges Pompidou; Universite Paris Descartes, France)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Volume:   542
Dimensions:   Width: 15.10cm , Height: 3.00cm , Length: 22.90cm
Weight:   1.040kg
ISBN:  

9780124166189


ISBN 10:   0124166180
Pages:   536
Publication Date:   29 May 2014
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

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Lorenzo Galluzzi received his Ph.D. in 2008 from the University of Paris Sud/Paris XI, France, and now works as a Research Manager in the laboratory of Guido Kroemer. He is particularly fascinated by several aspects of mitochondrial cell death, oncometabolism and tumor immunology. Guido Kroemer received his M.D. in 1985 from the University of Innsbruck, Austria, and his Ph.D. in 1992 from the Autonomous University of Madrid, Spain. He now works as a Research Director at the French Medical Research Council (INSERM) in Villejuif, France, as a Full Professor at the University of Paris Descartes, France, and as a hospital practitioner at the Hopital Europeen George-Pompidou, Paris, France. His research interests encompass mitochondrial cell death, autophagy and the immune response to dying cancer cells.

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