Overview

Computational Modelling of Biomechanics and Biotribology in the Musculoskeletal System reviews how a wide range of materials are modelled and how this modelling is applied. Computational modelling is increasingly important in the design and manufacture of biomedical materials, as it makes it possible to predict certain implant-tissue reactions, degradation, and wear, and allows more accurate tailoring of materials' properties for the in vivo environment. Part I introduces generic modelling of biomechanics and biotribology with a chapter on the fundamentals of computational modelling of biomechanics in the musculoskeletal system, and a further chapter on finite element modelling in the musculoskeletal system. Chapters in Part II focus on computational modelling of musculoskeletal cells and tissues, including cell mechanics, soft tissues and ligaments, muscle biomechanics, articular cartilage, bone and bone remodelling, and fracture processes in bones. Part III highlights computational modelling of orthopedic biomaterials and interfaces, including fatigue of bone cement, fracture processes in orthopedic implants, and cementless cup fixation in total hip arthroplasty (THA). Finally, chapters in Part IV discuss applications of computational modelling for joint replacements and tissue scaffolds, specifically hip implants, knee implants, and spinal implants; and computer aided design and finite element modelling of bone tissue scaffolds. This book is a comprehensive resource for professionals in the biomedical market, materials scientists and mechanical engineers, and those in academia.

Full Product Details

Author:   Z Jin (Professor of Computational Bioengineering, University of Leeds, UK)
Publisher:   Elsevier Science & Technology
Imprint:   Woodhead Publishing Ltd
Dimensions:   Width: 15.60cm , Height: 2.90cm , Length: 23.40cm
Weight:   0.780kg
ISBN:  

9780081014073

ISBN 10:   0081014074
Pages:   550
Publication Date:   30 October 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Available To Order  
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Table of Contents

Contributor contact details Woodhead Publishing Series in Biomaterials Foreword Preface Part I: Generic modelling of biomechanics and biotribology 1. Fundamentals of computational modelling of biomechanics in the musculoskeletal system Abstract: 1.1 Computational approach and its importance 1.2 Generic computational approach and important considerations 1.3 Computational methods and software 1.4 Future trends 1.5 Sources of further information and advice 1.6 References 2. Finite element modeling in the musculoskeletal system: generic overview Abstract: 2.1 The musculoskeletal (MSK) system 2.2 Overview of the finite element (FE) method 2.3 State-of-the-art FE modeling of the MSK system 2.4 Key modeling procedures and considerations 2.5 Challenges and future trends 2.6 References 3. Joint wear simulation Abstract: 3.1 Introduction 3.2 Classification of wear 3.3 Analytic and theoretical modelling of wear 3.4 Implementation of wear modelling in the assessment of joint replacement 3.5 Validating wear models 3.6 Future trends 3.7 References 3.8 Appendix: useful tables Part II: Computational modelling of musculoskeletal cells and tissues 4. Computational modeling of cell mechanics Abstract: 4.1 Introduction 4.2 Mechanobiology of cells 4.3 Computational descriptions of whole-cell mechanics 4.4 Liquid drop models 4.5 Solid elastic models 4.6 Power-law rheology model 4.7 Biphasic model 4.8 Tensegrity model 4.9 Semi-flexible chain model 4.10 Dipole polymerization model 4.11 Brownian ratchet models 4.12 Dynamic stochastic model 4.13 Constrained mixture model 4.14 Bio-chemo-mechanical model 4.15 Computational models for muscle cells 4.16 Future trends 4.17 References 5. Computational modeling of soft tissues and ligaments Abstract: 5.1 Introduction 5.2 Background and preparatory results 5.3 Multiscale modeling of unidirectional soft tissues 5.4 Multiscale modeling of multidirectional soft tissues 5.5 Mechanics at cellular scale: a submodeling approach 5.6 Limitations and conclusions 5.7 Acknowledgments 5.8 References 6. Computational modeling of muscle biomechanics Abstract: 6.1 Introduction 6.2 Mechanisms of muscle contraction: muscle structure and force production 6.3 Biophysical aspects of skeletal muscle contraction 6.4 One-dimensional skeletal muscle modeling 6.5 Causes and models of history-dependence of muscle force production 6.6 Three-dimensional skeletal muscle modeling 6.7 References 7. Computational modelling of articular cartilage Abstract: 7.1 Introduction 7.2 Current state in modelling of articular cartilage 7.3 Comparison and discussion of major theories 7.4 Applications and challenges 7.5 Conclusion 7.6 References 8. Computational modeling of bone and bone remodeling Abstract: 8.1 Introduction 8.2 Computational modeling examples of bone mechanical properties and bone remodeling 8.3 Results of computational modeling examples 8.4 Conclusion and future trends 8.5 Sources of further information and advice 8.6 Acknowledgments 8.7 References 9. Modelling fracture processes in bones Abstract: 9.1 Introduction 9.2 A brief update on the literature 9.3 Physical formulation and modelling methods 9.4 Results and discussion 9.5 Challenges, applications and future trends 9.6 Sources of further information and advice 9.7 Acknowledgement 9.8 References Part III: Computational modelling of orthopaedic biomaterials and interfaces 10. Modelling fatigue of bone cement Abstract: 10.1 Introduction 10.2 Modelling fatigue of bulk cement 10.3 Cement-implant interface 10.4 Cement-bone interface 10.5 Current and future trends 10.6 Conclusion 10.7 References 11. Modelling fracture processes in orthopaedic implants Abstract: 11.1 Introduction 11.2 The fracture mechanics approach 11.3 Mechanical properties 11.3.5 Fracture resistance 11.3.6 Impact strength 11.3.7 Hardness 11.3.8 Fragility 11.3.9 Abrasion 11.4 Determination of fracture mechanics parameters 11.5 Overview of computer methods used in mechanics 11.6 Simulation and modelling of the crack path in biomaterials 11.7 Challenges and future trends 11.8 References 12. Modelling cementless cup fixation in total hip arthroplasty (THA) Abstract: 12.1 Cup fixation in acetabular bone stock 12.2 Measurement and numerical analysis of cup fixation 12.3 Summary of the relevant literature 12.4 Materials and assumptions 12.5 Modelling methods and details 12.6 Understanding and interpretation 12.7 Challenges, applications and future trends 12.8 References Part IV: Applications of computational modelling for joint replacements and tissue scaffolds 13. Computational modeling of hip implants Abstract: 13.1 Introduction 13.2 Modeling and methods 13.3 Results 13.4 Discussion 13.5 Future trends 13.6 Conclusion 13.7 References 14. Computational modelling of knee implants Abstract: 14.1 Introduction 14.2 Application of computational models in analysis of knee implants 14.3 Assumptions for kinematics and kinetics 14.4 Model definition 14.5 Model formulation 14.6 Model solution 14.7 Model validation 14.8 Conclusion, challenges and future trends 14.9 Sources of further information and advice 14.10 References 15. Computational modelling of spinal implants Abstract: 15.1 Introduction 15.2 Spine and implant computational biomechanics 15.3 Numerical assessments of spinal implants 15.4 Future trends 15.5 Conclusion 15.6 References 16. Finite element modelling of bone tissue scaffolds Abstract: 16.1 Introduction 16.2 Fundamentals of computational mechanobiology 16.3 Applications of finite element modelling (FEM) and computational mechanobiology to bone tissue engineering 16.4 Discussion 16.5 Conclusions and future trends 16.6 References Index

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Author Information

Prof. Jin is Professor of Computational Bioengineering at the Institute of Medical and Biological Engineering, and Visiting Honorary Professor for Mechanical Engineering, University of Leeds, UK. His research interests are joint replacement and substitution, tissue re-engineering, and functional spinal interventions, focusing on improving function using structural biomaterials.

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