Overview

The material in the book covers a deliberately wide range of topics concerning the study and modelling of biomolecules (DNA, RNA, proteins) using computer techniques. Methods for structure determination and predictions, the analysis of structure-sequence databases and the computer based design of molecules are presented along with approaches for modelling the dynamic behaviour of biomolecules and treating complex solvent effects on their structure in solution. Several specific system applications illustrate what can be achieved. The reader is shown recent developments in a very active research area at the intersection of molecular biology, physical chemistry and computer science.

Full Product Details

Author:   Dikeos M. Soumpasis ,  Thomas M. Jovin
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Weight:   0.560kg
ISBN:  

9783540559511

ISBN 10:   3540559515
Pages:   237
Publication Date:   14 December 1992
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Structure Analysis and Prediction.- Structure Determination from NMR - Application to Crambin.- From Sequence Similarity to Structural Homology of Proteins.- Equilibrium Distribution of Secondary Structures for Large RNA.- Doing sequence analysis by inspecting the order in which neural networks learn.- Computational Approaches to Nucleic Acid Structure.- A New Program for the Analysis of Nucleic Acid Structure: Implications for Nucleic Acid Structure Interpretation.- Modeling DNA Backbone Structures.- Specific Systems.- Serine and Cysteine Proteases and their Natural Inhibitors: Structures and Implications for Function and Drug Design.- Principles of Protein - Protein Recognition in Protease-Inhibitor and Antigen-Antibody Complexes.- Subtleties in Designing DNA Sequence Specific Ligands.- The Structure of DNA Four-Way Junctions.- Physical Chemistry and Dynamics.- Rapid Conformational Investigations of Organic Molecules.- Dynamics of DNA Oligomers: Harmonic and Anharmonic Motions.- Surface Boundary Conditions: A Simulation Model for Macromolecules.- Computation of Ionic Distributions around Charged Biomolecular Structures using the PMF Approach.- Formal Aspects of the Potential of Mean Force Approach.- List of Contributors.

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