Overview

The time seems ripe for a critical compendium of that segment of the biological universe we call viruses. Virology, as a science, having passed only recently through its descriptive phase of naming and num­ bering, has probably reached that stage at which relatively few new-truly new-viruses will be discovered. Triggered by the intellectual probes and techniques of molecular biology, genetics, bio­ chemical cytology, and high resolution microscopy and spec­ troscopy, the field has experienced a genuine information explosion. Few serious attempts have been made to chronicle these events. This comprehensive series, which will comprise some 6000 pages in a total of about 18 volumes, represents a commitment by a large group of active investigators to analyze, digest, and expostulate on the great mass of data relating to viruses, much of which is now amorphous and disjointed, and scattered throughout a wide literature. In this way, we hope to place the entire field in perspective, and to develop an invalua­ ble reference and sourcebook for researchers and students at all levels. This series is designed as a continuum that can be entered anywhere, but which also provides a logical progression of developing facts and integrated concepts.

Full Product Details

Author:   Heinz Fraenkel-Conrat
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 1979
Volume:   15
Dimensions:   Width: 17.00cm , Height: 1.70cm , Length: 24.40cm
Weight:   0.542kg
ISBN:  

9781461330110

ISBN 10:   1461330114
Pages:   294
Publication Date:   06 October 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1 Immune Responses, Immune Tolerance, and Viruses.- 1. Introduction.- 2. Immune System.- 3. Immune Responses in Nonviral Systems.- 4. Immune Responses in Viral Systems.- 5. Immune Tolerance in Viral Systems.- 6. Conclusion.- 7. References.- 2 Interaction of Viruses with Neutralizing Antibodies.- 1. Introduction.- 2. Methods.- 3. Antibody.- 4. Antigen-Antibody Interaction.- 5. Neutralization.- 6. Viral Neutralization.- 7. The Nonneutralized Fraction (NNF).- 8. Neutralization by Antibody Fragments.- 9. Virolysis.- 10. Mechanisms.- 11. General Concluding Comments.- 12. References.- 3 Humoral Immunity to Viruses.- 1.Introduction.- 2. The Complement System.- 3. General Considerations of Virus Structure and Interactions with Humoral Elements.- 4. Nonimmune Non-Complement-Related Humoral Viral Neutralizing Factors.- 5. Antibody-Dependent Viral Neutralization.- 6. General Features of Antibody- and Complement-Dependent Viral Neutralization.- 7. Antibody- and Complement-Dependent Viral Neutralization: Nonlytic Mechanisms.- 8. Antibody- and Complement-Dependent Viral Neutralization: Lytic Mechanisms.- 9. Nonimmune Complement-Dependent Viral Inactivation.- 10. Conclusions.- 11. References.- 4 Cellular Immune Response to Viruses and the Biological Role of Polymorphic Major Transplantation Antigens.- 1. Introduction.- 2. Cellular Immunity and the Major Histocompatibility Gene Complex.- 3. Antigens Involved in Immune Recognition: Viral Antigens and Self Antigens Coded by the Major Histocompatibility Gene Complex.- 4. MHC Restriction and Immune Responsiveness.- 5. Polymorphism of MHC Products and MHC-Linked Susceptibility to Disease.- 6. References.- 5 Interferons.- 1. Introduction.- 2. Interferon Synthesis.- 3. Mechanisms of the Antiviral Activity.- 4. Molecular Characterization of Interferons.- 5. Interaction with the Immune System.- 6. Antitumor and Cell Multiplication Inhibitory Effects.- Type II Interferon.- 8. Summary and Conclusions.- 9. References.

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