Overview

Carbohydrates are an important part of life and are present in bacteria, fungi, viruses, yeast, plants, animals and humans. The rapid expansion of chemistry and glycobiology over the last few years has provided many new, imaginative and efficient techniques which provide further insight into the structures and biological interactions of carbohydrates and glycostructures. Comprehensive Glycoscience has a very broad scope and will appeal to a wide audience as it explores the interactions between biology, chemistry and molecular biology towards understanding, synthesising and developing glycoproteins, glycolipids, proteoglyans and polysaccharides, which are important molecules in nature for controlling health and disease and food and feed. Glycocompounds reviewed include: oligosaccharides, polysaccharides, glycoproteins, glycolipids, glycoconjugates, lectins, cellulose, pectins and starch. Topics covered include: spectroscopy, nomenclature, structures, synthesis, biosynthesis, molecular interactions, degradation, biochemistry, glycobiology, glycotherapeutics and diseases.

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9780444527462

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Reviews

Named a CHOICE Outstanding Academic Title for 2008! CHOICE Magazine Review, April 2008: This four-volume set is probably the most extensive coverage of the rapidly growing and very important field of glycoscience that is currently available. The scope of these volumes includes both strict carbohydrates (e.g., monosaccharides, oligosaccharides, polysaccharides) and carbohydrate-containing substances (e.g., glycoproteins, glycosphingolipids, peptidoglycans). Major areas of content include nomenclature and basic structure, synthesis, analysis, functional properties, biochemistry, carbohydrate-mediated interactions, biological systems and development, and health and disease. On average, coverage in each area is broken down into 15 chapters, each examining a specific subtopic in great depth. There are extensive, up-to-date references throughout. In addition to a complete index for the entire set at the end of volume 4, each volume has its own exhaustive index...Summing Up: Recommended. Upper-division undergraduates through professionals.

Named a CHOICE Outstanding Academic Title for 2008! CHOICE Magazine Review, April 2008: This four-volume set is probably the most extensive coverage of the rapidly growing and very important field of glycoscience that is currently available. The scope of these volumes includes both strict carbohydrates (e.g., monosaccharides, oligosaccharides, polysaccharides) and carbohydrate-containing substances (e.g., glycoproteins, glycosphingolipids, peptidoglycans). Major areas of content include nomenclature and basic structure, synthesis, analysis, functional properties, biochemistry, carbohydrate-mediated interactions, biological systems and development, and health and disease. On average, coverage in each area is broken down into 15 chapters, each examining a specific subtopic in great depth. There are extensive, up-to-date references throughout. In addition to a complete index for the entire set at the end of volume 4, each volume has its own exhaustive index...Summing Up: Recommended. Upper-division undergraduates through professionals.

Named a CHOICE Outstanding Academic Title for 2008! CHOICE Magazine Review, April 2008: This four-volume set is probably the most extensive coverage of the rapidly growing and very important field of glycoscience that is currently available. The scope of these volumes includes both strict carbohydrates (e.g., monosaccharides, oligosaccharides, polysaccharides) and carbohydrate-containing substances (e.g., glycoproteins, glycosphingolipids, peptidoglycans). Major areas of content include nomenclature and basic structure, synthesis, analysis, functional properties, biochemistry, carbohydrate-mediated interactions, biological systems and development, and health and disease. On average, coverage in each area is broken down into 15 chapters, each examining a specific subtopic in great depth. There are extensive, up-to-date references throughout. In addition to a complete index for the entire set at the end of volume 4, each volume has its own exhaustive index...Summing Up: Recommended. Upper-division undergraduates through professionals.

Author Information

Dr. Barchi received his Ph.D. in Synthetic/Marine Natural Products Chemistry from the University of Hawaii and was a postdoctoral fellow at Duke University. He then joined the National Cancer Institute as a staff fellow in the Laboratory of Medicinal Chemistry in1988 where he rose to his current position of Senior Scientist/Principal Investigator and NMR Facility Head at the newly formed Chemical Biology Laboratory. His main research interests are in synthetic medicinal chemistry as it relates to carbohydrate-based drug design, the development of novel sugar-conjugated nanoparticles and the high-resolution structural analysis of sugars, glycopeptides and small molecule drug candidates by NMR spectroscopy. Dr Barchi's career at the NCI has spanned a wide breadth of drug discovery efforts, including the synthesis of PKC and reverse transcriptase inhibitors, the development of glycopeptide antigens as vaccine candidates against HIV and cancer, as well as the discovery of several glycopeptide-analogues of Antiproliferative Factor (APF), a negative growth factor isolated from patients with interstitial cystitis. Current focus in the lab is the discovery of novel nanoplatforms for the delivery and therapeutic applications of immunogenic glycopeptides, the search for selective antitumor agents based on APF and the conformational analysis of these synthetic analogues by NMR spectroscopy to guide further discovery efforts. He is on the editorial board of Current Cancer Drug Targets (Bentham Science Publishers) and Carbohydrate Research (Elsevier) and was a guest editor for Current Topics in Medicinal Chemistry (Bentham Science Publishers), on The Art of Drug Design and Discovery. He has an h-index of 35.

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