Overview

Now in a revised edition, Comparative Pharmacokinetics: Principles, Techniques, and Applications presents the principles and techniques of comparative and veterinary pharmacokinetics in a detailed yet practical manner. Developed as a tool for ensuring that pharmacokinetics studies are properly designed and correctly interpreted, the book provides complete coverage of the conceptual basis of pharmacokinetics as used for quantifying biological processes from the perspectives of physiology and medicine.  New chapters have been added on quantitative structure permeability relationships and bioequivalence, and a number of existing chapters have been significantly revised and expanded to provide a current resource for veterinary and comparative pharmacokinetics.

Full Product Details

Author:   Jim E. Riviere (North Carolina State University, North Carolina, USA)
Publisher:   John Wiley and Sons Ltd
Imprint:   Wiley-Blackwell
Edition:   2nd edition
Dimensions:   Width: 18.00cm , Height: 2.70cm , Length: 25.20cm
Weight:   1.043kg
ISBN:  

9780813829937

ISBN 10:   0813829933
Pages:   376
Publication Date:   25 March 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

Coauthors. Preface. 1 Introduction. 2 Principles of Drug Movement in the Body. 3 Quantitative Structure–Permeability Relationships (Xin-Rui Xia). 4 Absorption. 5 Distribution (with Jennifer Buur). 6 Renal Elimination. 7 Hepatic Biotransformation and Biliary Excretion (Ronald Baynes). 8 Compartmental Models. 9 Noncompartmental Models. 10 Nonlinear Models. 11 Physiological Models (Teresa Leavens). 12 Dosage Regimens. 13 Simultaneous Pharmacokinetic–Pharmacodynamic Modeling (Pierre-Louis Toutain). 14 Study Design and Data Analysis. (Jason Chittenden). 15 Bioequivalence Studies (Marilyn Martinez). 16 Population Pharmacokinetic Models (Jason Chittenden). 17 Dosage Adjustments in Disease States (Jennifer Davis). 18 Interspecies Extrapolations. 19 Tissue Residues and Withdrawal Times (Sharon Mason). Index.

Reviews

This book is helpful in understanding and designing pharmacokinetic studies, illustrating basic concepts and noting the species differences... The book does a good job of explaining a concept and then expands with more specific examples. It provides a good base for pharmacokinetic modeling and illustrates the pitfalls with interspecies extrapolation. (Doody's, 21 October 2011)

This book is helpful in understanding and designingpharmacokinetic studies, illustrating basic concepts and noting thespecies differences... The book does a good job of explaining aconcept and then expands with more specific examples. It provides agood base for pharmacokinetic modeling and illustrates the pitfallswith interspecies extrapolation. (Doody's, 21 October 2011) <p>

This book is helpful in understanding and designing pharmacokinetic studies, illustrating basic concepts and noting the species differences. . . The book does a good job of explaining a concept and then expands with more specific examples. It provides a good base for pharmacokinetic modeling and illustrates the pitfalls with interspecies extrapolation. (Doody's, 21 October 2011)<p>

Author Information

Jim Riviere, DVM, PhD, DSc (hon), ATS, is the Burroughs Wellcome Fund Distinguished Professor of Pharmacology, Alumni Distinguished Graduate Professor, and Director of the Center for Chemical Toxicology Research and Pharmacokinetics at North Carolina State University, and Editor of the Journal of Veterinary Pharmacology and Therapeutics.

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