Overview

This study focuses on the evolving linear structure of the genome, from organelles and prokaryotes through to the multichromosomal nuclear genomes of plants and animals, based on modern genome map and sequence data. The collection brings together the diverse range of combinatorial optimization and probabilistic modeling techniques for analyzing genome rearrangements in the context of clinical cytogenetics, molecular genetics, population biology, microbial genomics, and the domesticated plant and animal genome projects. It critically compares functional and neutral conceptions of genome rearrangement and represents a concerted attack on the modeling and analytical problems associated with gene and genome duplication and with multigene families.

Full Product Details

Author:   D. Sankoff ,  J.H. Nadeau
Publisher:   Springer
Imprint:   Springer
Edition:   Softcover reprint of the original 1st ed. 2000
Volume:   1
Dimensions:   Width: 15.50cm , Height: 2.90cm , Length: 23.50cm
Weight:   1.770kg
ISBN:  

9780792365846

ISBN 10:   0792365844
Pages:   557
Publication Date:   30 September 2000
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Comparative Genomics.- 1. Mechanisms.- Cytogenetics, Molecular Genetics, Population Genetics.- Benefits of a Model of Segregation for the Understanding of Chromosomal Evolution.- Fixation of Chromosomal Rerrangements.- The Pathological Consequences and Evolutionary Implications of Recent Human Genomic Duplications.- High Frequency of Inversions During Eukaryote Gene Order Evolution.- Human and Mouse DNA Sequence Comparisons: Further Evidence for a Mosaic Model of Genomic Evolution.- Hot Spots in Chromosomal Breakage: From Description to Etiology.- 2. Organelles: Mitochondria and Chloroplats.- Rearrangements in Small Genomes.- Chloroplast Gene Order and the Divergence of Plants and Algae, from the Normalized Number of Induced Breakpoints.- An Empirical Comparison of Phylogenetic Methods on Chloroplast Gene Order Data in Campanulaceae.- Gene Order and Phylogenetic Information.- The Duplication/Random Loss Model for Gene Rearrangement Exemplified by Mitochondrial Genomes of Deuterostome Animals.- MAPIT—A Semi-Automated Approach to the Representation of Genetic Maps.- 3. Combinatorial Algorithms.- A New Set of Problems for a New Kind of Data.- Experimental and Statistical Analysis of Sorting by Reversals.- The Syntenic Diameter of the Space of N-Chromosome Genomes.- Circular Permutations and Genome Shuffling.- The Complexity of Calculating Exemplar Distances.- An Alternative Algebraic Formalism for Genome Rearrangements.- Approximation Algorithms for the Median Problem In the Breakpoint Model.- Algorithms for Constructing Comparative Maps.- 4. Prokaryotes.- Genome Scrambling versus- Functional Clustering.- Dynamics of Gene Order Structures and Genomic Architectures.- Comparative Genome Analysis: Exploiting the Context of Genes to Infer Evolution and Predict Function.- 5.Statistics.- The Quantification of Comparative Mapping.- Accuracy and Robustness of Analyses Based on Numbers of Genes in Observed Segments.- Marker Density and Estimates of Chromosome Rearrangement.- Estimating the Number of Conserved Segments Between Species Using a Chromosome Based Model.- CHROMTREE: Maximum Likelihood Estimation of Chromosomal Phylogenies.- 6. Nuclear Genomes.- Evolutionary Inference from Comparative Mapping.- Evolution of Karyotype Organisation in Accipitridae: a Translocation Model.- Syntenies of Unrelated Genes Conserved in Mammals and Nonvertebrates (A Review).- Companion Animal Genetics.- The Essential Role of Comparative Maps in Livestock Genomics.- Comparative Genetics: From Hexaploid Wheat to Arabidopsis.- Unraveling Crucifer Genomes Through Comparative Mapping.- Comparative Genomics of Plant Chromosomes.- 7. Gene and Genome Duplication and Multi-gene Families.- How Can Duplication be Analyzed?.- Recovery of Ancestral Tetraploids.- Genome Archaeology: Detecting Ancient Polyploidy in Contemporary Genomes.- Polyploidization and Vertebrate Origins: A Review of the Evidence.- A Formal Model of Genomic DNA Multiplication and Amplification.- A Simple Evolutionary Model for Genome Phylogeny Based on Gene Content.- GENETREE: A Tool for Exploring Gene Family Evolution.- Duplication, Rearrangement, and Reconciliation.- Author Index.

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