Overview

Combinatorial chemistry, by accelerating the process of chemical synthesis, is having a profound effect on all branches of chemistry, but especially on drug discovery. This informative text explains the origins of combinatorial chemistry and puts the many diverse library methods into context. It explains why some techniques are generally applicable and others are for specialists only. It also focuses on the renaissance of solid phase chemistry and describes the range of available reactions. This is the first single author book in this important, growing field and it describes the beneficial impact of combinatorial chemistry, espcially for the discovery and optimization of biologically active molecules.This concise and comprehensive overview of combinatorial techniques is an essential text for final year undergraduates, postgraduates, academics, and industrialists in chamistry, bioorganic chemistry, medicinal chemistry, and drug discovery. it provides an accessible introduction to the area for those new to these methods and a valuable reference text to those experienced in the field.

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9780198502197

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Reviews

<br> Terrett's timely book discusses the practical and economic advantages of the combinatorial approach in the synthesis of libraries of compounds used in drug discovery. Combinatorial chemistry made its debut in 1991, using the discovery of the Merrifield polypeptide synthesis (1963) as a starting point. The combinatorial method is employed in making pure compounds and mixtures in the search for biological activity. Because of its rapidity, low cost, and the potential to generate large numbers of diverse compounds, the combinatorial approach is used extensively by pharmaceutical companies. This technology has provided previously unknown leads that can be followed up by the synthesis of single compounds, which optimize the efficacy of the lead structures. . . . Excellent illustrations supplement the discussions. Other features include chapter references, a brief index, and a most welcome table of abbreviations. Upper-division undergraduates through professionals. --Choice<br>

Terrett's timely book discusses the practical and economic advantages of the combinatorial approach in the synthesis of libraries of compounds used in drug discovery. Combinatorial chemistry made its debut in 1991, using the discovery of the Merrifield polypeptide synthesis (1963) as a starting point. The combinatorial method is employed in making pure compounds and mixtures in the search for biological activity. Because of its rapidity, low cost, and the potential to generate large numbers of diverse compounds, the combinatorial approach is used extensively by pharmaceutical companies. This technology has provided previously unknown leads that can be followed up by the synthesis of single compounds, which optimize the efficacy of the lead structures. . . . Excellent illustrations supplement the discussions. Other features include chapter references, a brief index, and a most welcome table of abbreviations. Upper-division undergraduates through professionals. --Choice

`The book is a very useful addition to the area at the undergraduate level, as well as providing a rudimentary introduction for those chemists new to the field. All the basics are covered, ranging from solid supports to linkers to examples of reliable non-peptide solidphase chemistries, as well as the more exotic, with regards to tagging and single bead screening.' Mark Bradley, Chemistry in Britain, March 1999,

The book is a very useful addition to the area at the undergraduate level, as well as providing a rudimentary introduction for those chemists new to the field. All the basics are covered, ranging from solid supports to linkers to examples of reliable non-peptide solidphase chemistries, as well as the more exotic, with regards to tagging and single bead screening. Mark Bradley, Chemistry in Britain, March 1999,

<br> Terrett's timely book discusses the practical and economic advantages of the combinatorial approach in the synthesis of libraries of compounds used in drug discovery. Combinatorial chemistry made its debut in 1991, using the discovery of the Merrifield polypeptide synthesis (1963) as a starting point. The combinatorial method is employed in making pure compounds and mixtures in the search for biological activity. Because of its rapidity, low cost, and the potential to generate large numbers of diverse compounds, the combinatorial approach is used extensively by pharmaceutical companies. This technology has provided previously unknown leads that can be followed up by the synthesis of single compounds, which optimize the efficacy of the lead structures. . . . Excellent illustrations supplement the discussions. Other features include chapter references, a brief index, and a most welcome table of abbreviations. Upper-division undergraduates through professionals. --Choice<p><br>

`The book is a very useful addition to the area at the undergraduate level, as well as providing a rudimentary introduction for those chemists new to the field. All the basics are covered, ranging from solid supports to linkers to examples of reliable non-peptide solidphase chemistries, as well as the more exotic, with regards to tagging and single bead screening.' Mark Bradley, Chemistry in Britain, March 1999,

Terrett's timely book discusses the practical and economic advantages of the combinatorial approach in the synthesis of libraries of compounds used in drug discovery. Combinatorial chemistry made its debut in 1991, using the discovery of the Merrifield polypeptide synthesis (1963) as a starting point. The combinatorial method is employed in making pure compounds and mixtures in the search for biological activity. Because of its rapidity, low cost, and the potential to generate large numbers of diverse compounds, the combinatorial approach is used extensively by pharmaceutical companies. This technology has provided previously unknown leads that can be followed up by the synthesis of single compounds, which optimize the efficacy of the lead structures. . . . Excellent illustrations supplement the discussions. Other features include chapter references, a brief index, and a most welcome table of abbreviations. Upper-division undergraduates through professionals. --Choice<br>

Author Information

Dr Nicholas K Terrett, Section Head, Discovery Chemistry, Pfizer Central Research, Pfizer Ltd., Sandwich, Kent CT13 9NJ. Tel: 01304 618451. Fax: 01304 618422. Email: nick terrett@sandwich.pfizer.com

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