Overview
The new time-saving revolution in drug discovery. Combinatorial chemistry, a method for synthesizing millions of chemical compounds much faster than usual, is becoming one of the most useful technical tools available to chemists and researchers working today. Using current advances in computer and laboratory techniques, combinatorial chemistry has freed professionals from the drudgery of piecemeal experimental work and opened new creative possibilities for experimentation. Combinatorial Chemistry: Synthesis and Application details critical aspects of the technique, featuring the work of some of the world's leading chemists, many of whom played a key role in its development. Including examples of both solution-phase and solid-phase approaches as well as the full complement of organic chemistry technologies currently available, the book describes: * Concepts and terms of combinatorial chemistry * Polymer-supported synthesis of organic compounds * Macro beads as microreactors * Solid-phase methods in combinatorial chemistry * Encoded combinatorial libraries, including Rf-encoding of synthesis beads * Strategies for combinatorial libraries of oligosaccharides * Combinatorial libraries of peptides, proteins, and antibodies using biological systems. While combinatorial chemistry originated in peptide chemistry, this volume has deliberately focused on nonpeptide organic applications, illustrating the technique's wide uses. Combinatorial Chemistry introduces organic, medicinal, and pharmaceutical chemists as well as biochemists to this exciting, cost-effective, and practical technique, which has unlocked creative potential for the next millennium.
Full Product Details
Author: Stephen R. Wilson (New York University) ,
Anthony W. Czarnik (IRORI Quantum Microchemistry)
Publisher: John Wiley & Sons Inc
Imprint: Wiley-Interscience
Dimensions:
Width: 16.30cm
, Height: 2.00cm
, Length: 24.20cm
Weight: 0.596kg
ISBN: 9780471126874
ISBN 10: 047112687
Pages: 288
Publication Date: 08 April 1997
Audience:
College/higher education
,
Professional and scholarly
,
Postgraduate, Research & Scholarly
,
Professional & Vocational
Format: Hardback
Publisher's Status: Active
Availability: Out of stock
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.
Author Information
Stephen R. Wilson is Professor of Chemistry at New York University. He is also founder and President of Sphere Biosystems, Inc., in New Jersey, a biotech company based on fullerene combinatorial chemistry technology. Anthony W. Czarnik is Senior Director of Chemistry at IRORI Quantum Microchemistry in La Jolla, California, and formerly Director of BioOrganic Chemistry at Parke-Davis Pharmaceutical Research.
