Overview

This book consists of contributions from the most prominent experts in this field. In the first section the general principles of combination treatment are discussed, from rationale and methodology to benefits of risks in daily practice. The second section concerns specific diseases. It is striking that although there is so much experience with combining DMARDS in RA, for several other autoimmune diseases combination therapy has not yet been developed. Denton and Black, on the other hand, are able to add a refreshing new meaning to the term ""combination therapy"" in systemic sclerosis by pointing out the aetiologies beyond those caused by immunopathology, and dealing with combinations of therapy to address issues beyond immunotherapy. The last section is devoted to the future, and the editors hope to come back in 2010 with an issue which will look back and determine whether the predictions of Brooks, Moore, Huizinga and Breedveld have come true.

Full Product Details

Author:   W.B. Harrison ,  B.A.C. Dijkmans
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of hardcover 1st ed. 2002
Dimensions:   Width: 15.50cm , Height: 1.10cm , Length: 23.50cm
Weight:   0.454kg
ISBN:  

9783642077043

ISBN 10:   3642077048
Pages:   213
Publication Date:   30 November 2010
Audience:   Professional and scholarly ,  Professional and scholarly ,  Professional & Vocational ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

I General Section.- Combination treatment in autoimmune diseases — Introduction.- Combination therapy for autoimmune diseases: the rheumatoid arthritis model.- Methodology of combination trials.- Regulatory aspects of evaluating combination treatments in autoimmune diseases.- New therapies in development for autoimmune diseases: their rationale for combination treatment.- Combination therapy: the risks of infection and tumor induction.- II Disease specific section.- Combination treatment in autoimmune diseases: Systemic lupus erythematosus.- Combination therapy in autoimmune disease: vasculitis.- Combination therapies for systemic sclerosis.- Therapy of Sjögren’s syndrome.- Spondylarthropathies: options for combination therapy.- Combination therapy in rheumatoid arthritis.- III Futurology.- What will treatment of autoimmune diseases entail in 2010?.- Stem cell transplantation for autoimmune diseases.

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