Overview

While the enzyme cascade that allows coagulation is well known physiologically, its elegant practical examples are vividly demonstrable in the clinical application of blood and components for the treatment of bleeding problems in surgery, trauma or in congenital deficiency in patients. This volume provides the fundamental and recent understanding relating to coagulation pathways, recombinant technology and other methods for coagulation factor production, up to date laboratory assay, preservation of cellular and plasma components, and their clinical use in surgery and medicine, including the immuno response to repeated challenge to contaminating protein in coagulation factor concentrates. The interrelated but multi-disciplinary chapters have been integrated in four sections: Principles and Fundamentals: Mechanism of thrombin formation; structure -- function relationship of coagulation proteins, role of calcium and anticoagulant: blood collection on haemostatic potential of plasma proteins and platelets; Factor VIII yields from anticoagulant exchanged plasma. Preservation Aspects: Platelet function preservation, platelet interaction with vessel wall; trends in the use of coagulation factor concentrate; immuno purification of Factor VIII; structural and fundamental properties of recombinant coagulation factors. Laboratory Aspects: Platelets counting and function testing; platelet crossmatch predictive value; clinical efficacy of platelet concentrate; protein C and protein S; principle of coagulation factor assay; standardisation of clotting factor assays; clinical efficacy of clotting factor concentrates. Clinical Consequences

Full Product Details

Author:   C.Th. Smit Sibinga ,  P.C. Das ,  P.M. Mannucci
Publisher:   Springer
Imprint:   Springer
Edition:   New edition
Volume:   26
Dimensions:   Width: 15.50cm , Height: 1.70cm , Length: 23.50cm
Weight:   1.290kg
ISBN:  

9780792313311

ISBN 10:   0792313313
Pages:   270
Publication Date:   30 September 1991
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

I. Principles and fundamentals.- The mechanisms of thrombin formation.- Structure-function relationships of human coagulation proteins.- The role of calcium in coagulation and anticoagulation.- Effect of blood collection on the hemostatic potential of coagulation proteins.- Factor VIII yields from anticoagulant exchanged Haemonetics Ultralite™ plasma.- Discussion.- II.Preservation aspects.- Platelet function preservation.- Platelet adhesion to the vessel wall.- Trends in the production and use of coagulation factor concentrates.- Immunoaffinity purification of Factor VIII/von Willebrand factor complex.- Structural and functional properties of recombinant coagulation factors.- Discussion.- III. Laboratory Aspects.- Platelet counting and function testing.- Selection of platelet apheresis donors for alloimmunized patients by ELISA platelet crossmatch versus HLA-matching.- Clinical efficacy of platelet concentrates.- Principles of coagulation factor assays.- Standardization of clotting factor assays.- Protein C and S in swiss blood donors.- Clinical efficacy of clotting factor concentrates: survival, recovery and hemostatic capacity.- Discussion.- IV. Clinical consequences.- Principles in the treatment of bleeding.- The effect of chronic exposure to clotting factor concentrates on the immune system.- Liver transplantation and blood usage.- The use of aprotinin in cardiopulmonary bypass and the impact on hemostasis and blood transfusion.- Discussion.

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