Clostridium difficile
Author:   K. Aktories ,  T.D. Wilkins
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Volume:   250
ISBN:  

9783540672913


Pages:   150
Publication Date:   06 July 2000
Format:   Hardback
Availability:   In Print   Availability explained
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Clostridium difficile


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Overview

Clostridium difficile has been recognized as the cause of a broad spectrum of enteric disease ranging from mild antibiotic-associated diarrhea to pseudomembranous colitis. This volume gives new insights into the microbiology, diagnostics and epidemiology of Clostridium difficile and describes recent strategies in treatment of diseases caused by this agent. Main parts of the volume are devoted to Clostridium difficile toxins A and B which are the major virulence factors. The molecular biology, biochemistry, pharmacology and cell biology of these toxins which are the prototypes of a new family of large clostridial cytotoxins is described in great detail. Clostridium difficile toxins act as glucosyltransferases to inactivate small GTP-binding proteins of the Rho family which are involved in regulation of the actin cytoskeleton, cell adhesion and various signaling processes.

Full Product Details

Author:   K. Aktories ,  T.D. Wilkins
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Volume:   250
Dimensions:   Width: 15.50cm , Height: 1.10cm , Length: 23.50cm
Weight:   0.910kg
ISBN:  

9783540672913


ISBN 10:   3540672915
Pages:   150
Publication Date:   06 July 2000
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print   Availability explained
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

List of Contents.- Microbiology, Epidemiology and Diagnosis of Clostridium difficile Infection.- Genetics of Clostridium difficile Toxins.- Molecular Mode of Action of the Large Clostridial Cytotoxins.- Cytotoxic Effects of the Clostridium difficile Toxins.- Large Clostridial Cytotoxins as Tools in Cell Biology.- Pathogenesis and Clinical Manifestations of Clostridium difficile Diarrhea and Colitis.- Treatment of Clostridium difficile-Associated Diarrhea and Colitis.

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