Overview

This third edition volume expands on the previous editions with updated chapters on longitudinal studies, randomized trials, evidence-based decisions making, and a new section on changing health-related behaviors. The chapters in this book are organized into six parts: Part One focuses on framing clinical research questions and choosing a suitable design; biases that may occur in clinical research; and the ethics associated with doing conducting research on humans. Parts Two through Four discuss designs, measurements, and analysis that pertain to evaluation of risk in longitudinal studies; assessment of therapy in controlled trials; and evaluation of diagnostic tests. Part Five presents methods used in various components of evidence-based decision-making; and Part Six highlights interventions focused on changing health-related behaviors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of various types of bias, step-by-step, readily reproducible protocols for different research designs, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Clinical Epidemiology: Methods and Protocols, Third Edition is a valuable resource for clinicians and researchers who want to expand their works to humans and use their findings in the health system.

Full Product Details

Author:   Patrick S. Parfrey ,  Brendan J. Barrett
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   3rd ed. 2021
Volume:   2249
Weight:   1.244kg
ISBN:  

9781071611401

ISBN 10:   1071611402
Pages:   650
Publication Date:   20 April 2022
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Preface…Table of Contents…Contributing Authors… Part I Introduction 1.   On Framing the Research Question and Choosing the Appropriate Research DesignPatrick S. Parfrey and Pietro Ravani 2.   Bias in Clinical ResearchSusan Stuckless and Patrick S. Parfrey 3.   Definitions of Bias in Clinical ResearchGeoffrey Warden 4.   Research Ethics for Clinical ResearchersJohn D. Harnett        5.  Ethical, Legal, and Social Issues (ELSI) in Clinical Genetics ResearchDaryl Pullman and Holly Etchegary Part II Longitudinal Studies 6.   Longitudinal Studies 1: Determinants of RiskSean W. Murphy 7.   Longitudinal Studies 2: Modeling Data using Multivariate AnalysisPietro Ravani, Brendan J. Barrett, and Patrick S. Parfrey 8.   Longitudinal Studies 3: Data Modeling using Standard Regression Models and ExtensionsPietro Ravani, Brendan J. Barrett, and Patrick S. Parfrey 9.   Longitudinal Studies 4: Matching Strategies to Evaluate RiskMatthew T. James 10. Longitudinal Studies 5: Development of Risk Prediction Models for Patients with Chronic DiseaseNavdeep Tangri and Claudio Rigatto  Part III Randomized Controlled Trials 11. Randomized Controlled Trials 1: DesignBryan M. Curtis, Brendan J. Barrett, and Patrick S. Parfrey 12. Randomized Controlled Trials 2: Analysis Robert N. Foley and Patrick S. Parfrey 13. Randomized Controlled Trials 3: Measurement and Analysis of Patient-Reported Outcomes Michelle M. Richardson and Klemens B. Meyer 14. Randomized Controlled Trials 4: Planning, Analysis, and Interpretation of Quality of Life StudiesRobert N. Foley and Patrick S. Parfrey 15. Randomized Controlled Trials 5: Biomarkers and Surrogates/OutcomesClaudio Rigatto and Brendan J. Barrett 16. Randomized Controlled Trials 6: Determining the Sample Size and Power for Clinical Trials and Cohort StudiesTom Greene 17. Randomized Controlled Trials 7: On Contamination and Estimating the Actual Treatment Effect      Patrick S. Parfrey  Part IV Other Clinical Epidemiology Methods 18. Evaluation of Diagnostic TestsBrendan J. Barrett and John M. Fardy 19. Genetic Epidemiology of Complex PhenotypesDarren D. O’Rielly and Proton Rahman 20. Qualitative Research in Clinical EpidemiologyStephanie Thompson and Kara Schick-Makaroff   Part V Methods in Evidence-Based Decision Making 21. Evidence Based Decision Making 1: Critical Appraisal Laurie K. Twells 22. Evidence Based Decision Making 2: Systematic Review and Meta-Analysis Aminu Bello, Ben Vandermeer, Natasha Wiebe, Amit X. Garg, and Marcello Tonelli 23. Evidence-Based Decision Making 3: Health Technology AssessmentDaria O’Reilly, Richard Audas, Kaitryn Campbell, Meredith Vanstone, James M. Bowen, Lisa Schwartz, Nazila Assasi, and Ron Goeree 24. Evidence-Based Decision Making 4: Clinical Practice Guidelines      Tae Won Yi, Sine Donnellan, and Adeera Levin 25. Evidence-Based Decision Making 5: Knowledge Translation and the Knowledge to Action CycleBraden J. Manns 26. Evidence-Based Decision Making 6: Administrative Databases as Secondary Data Source for Epidemiologic and Health Service ResearchTanvir Turin Chowdhury and Brenda R. Hemmelgarn 27. Methods in Evidence-Based Decision Making 7: Health Economics in Clinical ResearchBraden J. Manns  28. Methods in Evidence-Based Decision Making 8: A Primer for Researchers      Victor Maddalena and Maisam Najafizada   Part VI Changing Health-Related Behaviors 29. Changing Health-Related Behaviors 1: Patient-Oriented Research and Patient Engagement in Health ResearchCatherine Street, Laurie K. Twells, Toni Leamon, Lynn Taylor, and Holly Etchegary 30. Changing Health-Care Behaviors 2: On Improving the Value of Health SpendingKaren Dickson, Robert Wilson, Owen Parfrey, and Patrick S. Parfrey 31. Changing Health-Related Behaviors 3: Lessons from Implementation ScienceAmanda Hall, Helen Richmond, Krista Mahoney, and James Matthews 32. Changing Health-Related Behaviors 4: Realizing Impact of Health Research through Knowledge TranslationKate Lambert, Krista Mahoney, and Patrick S Parfrey 33. Changing Health-Related Behaviors 5: On Interventions to Change Physician BehaviorsCheryl Etchegary, Lynn Taylor, Krista Mahoney, Owen Parfrey, and Amanda Hall 34. Changing Health-Related Behaviors 6: Analysis, Interpretation, and Application of Big DataRandy Giffen and Donald Bryant  Subject Index List…

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