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Author:   N.C. den Boer
Publisher:   Springer Science+Business Media
Imprint:   Kluwer Academic/Plenum Publishers
Edition:   1989 ed.
Weight:   1.700kg
ISBN:  

9780306430930

ISBN 10:   0306430932
Pages:   874
Publication Date:   01 February 1989
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

1.- The interaction between industry and the clinical chemist.- High resolution nuclear magnetic resonance spectroscopy in clinical chemistry and disease diagnosis.- Diagnostic related groups: the influence of refunding of cost on the organization of clinical laboratories.- The role of clinical chemistry in preventive medicine.- 2 Genes, Gene-Technology and DNA-Probes.- Recombinant DNA technology in the diagnosis of human inherited disease.- Pathogenesis and (prenatal) diagnosis of inherited diseases: Genetic heterogeneity and clinical diversity.- Molecular biology of the human aldolase isoenzyme gene family.- 3 Therapeutic Drug Monitoring and Toxicology.- Therapeutic drug monitoring and toxicology: relevance of measuring metabolites.- Biological monitoring of exposure to toxic trace elements.- Practical applications of therapeutic drug monitoring: the impact of technological developments.- Laboratory diagnosis of acute poisoning: consequences for treatment.- 4 Biosensors and Biochips.- Biosensors for medical use.- Enzyme sensors and immunosensors.- 5 Autoimmune Endocrinological and Neurological Disorders.- Antibodies to the thyrotropin (TSH) receptor and autoimmune thyroid disease.- Predicting type I diabetes.- Antibodies to acetylcholine receptors in myasthenia gravis.- Polyglandular autoimmune syndrome and bronchial asthma.- 6 Coagulation.- Fibrinolysis.- Modulation of endothelial cell coagulant properties.- Deficiencies of protein C and protein S and thromboembolic disease.- 7 Rheumatic Diseases.- Biochemical events in the destruction of cartilage in rheumatic diseases.- New immunological aspects in the pathogenesis and diagnosis of rheumatic diseases.- New biochemical parameters in diagnosis of joint diseases.- Clinical biochemistry of gout.- 8 Ion Selective Electrodes.- Ion selective electrodes (ISE’s) in clinical chemistry.- Proposed recommendations on ion-selective electrode determinations of the substance concentration of sodium, potassium and ionized calcium in serum plasma or whole blood.- The clinical application of ionized calcium.- Sodium and potassium by ion selective electrodes. Clinical interpretation.- 9 Bedside Chemistry and Selftesting.- Clinical Biochemistry — an integrated service.- Technology assessment of near-patient testing.- Bedside chemistry.- 10 Clinical Chemical Aspects of Transplantation.- Relevant issues in clinical organ transplantation.- Biochemical aspects of transplantation.- HLA Class II antigens-significance in organ transplantation.- Cytomegalovirus infections and transplantation rejection. Prognostic outlook of organ transplant recipients through an immunological view.- 11 Enzymology.- New perspectives in clinical enzymology.- Structure and function of disease-related allelozymes.- The clinical enzymology of the complement system.- 12 Chemi- and Bioluminescence.- Luminescence immunoassays.- Luminescence methods for substrate and enzyme determinations.- Phagocyte chemiluininescence and immune cell interaction.- Phagocytosis-independent chemiluminescence.- 13 Clinical Chemical Aspects of Ageing.- The ageing process: epidemiology, theories and model systems.- Changes during ageing in immunology, proteins, enzymes and hormones.- Clinical biochemistry of connective tissue and its role in ageing.- Biochemical and histopathological examination of the skin. Tool for prediction of coronary atherosclerosis.- 14 Laboratory Management and Cost Effectiveness.- Can the quality of laboratory testing be maintained at reduced cost?.- Management and organization of clinical chemistry and laboratory diagnostics in GDR.- The organization of the National Health Service and its consequence for the clinical chemical laboratory in Sweden.- The organization of the National Health Care and its consequences on the clinical chemistry laboratory in Nigeria.- 15 Lipids.- Clinical significance of lipoprotein particles.- Metabolic and endocrine aspects of cardiovascular risk factors. Observations on lipid metabolism in two “experiments of nature” and one experiment of human culture.- 16 Flowcytometry.- Cinical flow cytometry: history and horizons.- Current and future prospects of flow cytometry in clinical haematology.- 17 Clinical Chemistry and Nutrition.- Assessment of the B-vitamin status: some biochemical and clinical aspects.- Growth factors in malnutrition.- The use of biochemical parameters to evaluate and to estimate the nutritional status of kidney patients.- Clinical biochemical parameters to be used in general as indicators of malnutrition of children in developing countries.- 18 Mass-Spectrometry.- Principles and applications of mass spectrometry in clinical chemistry.- Modern mass spectrometric techniques applied to the analysis of steroids.- Mass spectrometry and the diagnosis and study of metabolic disease.- Isotope dilution — mass spectrometry as a reference method.- 19 Quality Assurance.- Expert systems for the clinical interpretation of laboratory reports.- Quality control in clinical laboratories.- 20 Human Infertility.- Clinical aspects of female infertility.- GIFT: Basic and clinical concepts of a new treatment for infertility of various cases.- Future possibilities in reproductive medicine.- 21 Clinical Immunology.- The multichain Interleukin-2 receptor: from the gene to the bedside.- New concepts in the etiopathogenesis of systemic lupus erythematosus.- IgE-mediated hypersensitivity.- Recent advances in our knowledge of complement.- 22 Regulatory Peptides.- Gamma-endorphin with deviant biological activity: a molecular marker for schizophrenia?.- Regulatory peptides in the control of food intake.- Regulatory peptides in health and disease.- b-Endorphin and reproduction: evidence for ovarian participation.- 23 The Thyroid and Functioning Hormones.- Cellular aspects of thyroid hormones.- Methods of analysis of thyroid-related hormones.- Thyrotropin secretion in health and disease.- 24 Veterinary Clinical Chemistry.- Biochemical disorders in nonhuman primates with hyperbilirubinemia.- Biochemical alterations in liver diseases of domestic animals.- Clinical chemistry in liver-toxicity testing: differences between species.- Lipid metabolism in large animals.- 25 Clinical Biochemistry in Developing Countries.- Clinical biochemistry in developing countries in Asia.- Clinical biochemistry services in tropical Africa.- Clinical biochemistry services in India.- Clinical biochemistry services in Indonesia.- Problems in clinical chemistry in developing countries: summary and possible solutions.- Author Index.

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