Overview

This book provides a state-of-the-art description of the current status of leukodepleted blood products. Advances in technology, particularly filtration, have achieved great success in the selective removal of these white cells. This has created a new challenge - the enumeration of white cells at low concentrations in filtered products. There may be benefits of the removal of such white cells on the quality of stored red cells and platelets. Improved safety may manifest as the attenuation of febrile reactions and reduction in sensitization to HLA antigens, viral disease transmission, transfusion associated immunomodulation, transfusion-related lung injury and reperfusion injury. Since white cell removal presents logistic problems and has cost implications, a cost-benefit analysis is essential to gauge the economic benefit of this approach. All of these aspects of white cell depleted products are discussed by acknowledged experts.

Full Product Details

Author:   Joseph Sweeney
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Edition:   Softcover reprint of the original 1st ed. 1995
Dimensions:   Width: 15.50cm , Height: 1.20cm , Length: 23.50cm
Weight:   0.338kg
ISBN:  

9781570591228

ISBN 10:   1570591229
Pages:   198
Publication Date:   01 January 1995
Audience:   College/higher education ,  Undergraduate
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

1. Introduction.- 2. Methods of Leukodepletion.- 3. Enumeration of Low White Cells.- 4. Mechanisms of Leukodepletion by Filtration.- 5. Role of Contaminating White Blood Cells in the Storage Lesions of Red Cells and Platelets.- 6. Leukodepletion to Prevent Transfusion Reactions: Effects on Cytokines and Other Biologic Response Modifiers.- 7. Leukodepletion and Alloimmunization.- 8. Role of Donor Leukocytes and Leukodepletion in Transfusion-Associated Viral Infections.- 9. Leukocyte Depletion and Transfusion-Induced Immunomodulation.- 10. The Role of Leukocyte Depletion in Prevention of Transfusion-Related Acute Lung Injury.- 11. The Role of Leukocyte Depletion in the Prevention of Reperfusion Injury Associated with Open Heart Surgery.- 12. The Use of Leukodepleted Blood Components for Neonates and Infants.- 13. Leukocyte Depleted Blood Transfusion in Hematopoietic Stem Cell Reconstitution Therapy.- 14. Cost-Effectiveness of Leukodepletion.

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