Overview

Capillary electrophoresis has expanded the clinical laboratory's ability to separate small, electrically neutral, molecules. Being a microtechnique, its use conserves precious samples and minimizes use of hazardous organic chemicals. This book is arranged into six sections providing an overview of the current use of CE in the clinical laboratory. The first section covers the history and some of the potential applications of CE as well as the principles necessary for the clinical laboratory scientists to understand the basics of CE. Section two covers the separation of proteins along with how CE is used to separate serum and CSF proteins, to detect serum and urine paraproteins, and the separation of lipoproteins and hemoglobin variants. The third section covers metabolic diseases that are usually detected by abnormalities in small molecules such as amino acids, organic acids or steroids. The fourth section covers the use of CE in immunoassays thus providing a simple, yet highly sensitive analysis technique. The fifth section describes the future of CE in the clinical laboratory, and its use in molecular diagnostics. The final section describes how CE can be used in conjunction with mass spectrometry, and it's potential use in therapeutic drug monitoring and clinical and forensic toxicology.

Full Product Details

Author:   John R. Petersen ,  Amin A. Mohammad
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2001 ed.
Dimensions:   Width: 15.20cm , Height: 2.50cm , Length: 22.80cm
Weight:   0.830kg
ISBN:  

9780896036451

ISBN 10:   0896036456
Pages:   454
Publication Date:   20 April 2001
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

1 Capillary Electrophoresis: General Overview and Applications in the Clinical Laboratory.- 2 Basic Principles and Modes of Capillary Electrophoresis.- 3 Capillary Coatings for Protein Analysis.- 4 Clinical Serum Protein Capillary Zone Electrophoresis.- 5 Serum and Urine Paraprotein Capillary Electrophoresis.- 6 Cerebrospinal Fluid Protein Electrophoresis.- 7 Lipoprotein Analysis.- 8 Clinical Analysis of Structural Hemoglobin Variants and Hb A1c by Capillary Isoelectric Focusing.- 9 Amino Acid Analysis.- 10 Organic Acids.- 11 Steroids.- 12 Capillary Electrophoresis Based Immunoassay.- 13 Quantitation of Viral Load.- 14 The Application of Capillary Electrophoresis in the Analysis of PCR Products Used in Forensic DNA Typing.- 15 Combining Capillary Electrophoresis with Electrospray Ionization Mass Spectrometry.- 16 Capillary Electrophoresis-Mass Spectrometry of Biologically Active Peptides and Proteins.- 17 Serum Drug Monitoring by Capillary Electrophoresis.- 18 Applications of Capillary Zone Electrophoresis in the Analysis of Metal Ions of Clinical Significance.- 19 Clinical and Forensic Drug Toxicology: Analysis of Illicit and Abused Drugs in Urine by Capillary Electrophoresis.- 20 Screening Biological Specimens for Drugs of Forensic Significance.

Reviews

This book fills a niche for those curious about this technology. It would be of greatest use to those with an academic interest in capillary electrophoresis. - Doody's Health Sciences Book Review Journal

This book fills a niche for those curious about this technology. It would be of greatest use to those with an academic interest in capillary electrophoresis. -Doody's Health Sciences Book Review Journal

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