Overview

Biological rhythms time the ebb and flow of virtually every physiological process, and their mutual coordination guarantees the integrity of the organism over space and time. Aging leads to the disintegration of this coordination, as well as to changes in the amplitude and/or frequency of the underlying rhythms. The results of this are accelerated loss of health during aging, and in experimental model systems curtailed lifespan occurs. This book will examine the machinery that constitutes circadian systems and how they impact physiologic processes. It will also discuss how disturbances of circadian rhythms can lead to complex diseases associated with aging. Much of this treatment will focus on metabolism and genome stability. Importantly, the chapters in this book will encompass work in several different models, in addition to human. The book will conclude with a discussion of modeling approaches to biologic cycles and chronotherapy, for future research and translation.

Full Product Details

Author:   S. Michal Jazwinski ,  Victoria P Belancio ,  Steven Hill
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   1st ed. 2017
Volume:   7
Weight:   0.887kg
ISBN:  

9783319645421

ISBN 10:   3319645420
Pages:   361
Publication Date:   03 November 2017
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Circadian dysregulation and melatonin rhythm suppression in the context of aging.- Pulmonary diseases, a matter of time.- Circadian regulation of bone.- Aging and the circadian control of the gastrointestinal system: from the brain to the gut microbiome (and back).- Circadian system and aging in rodent models.- The circadian system and aging of Drosophila.- Circadian control of mitochondrial dynamics.- Circadian rhythms and proteostasis in aging.- Circadian clocks and mTOR signaling.- Aging and the biological clock.- Developing circadian therapeutics against age-related metabolic decline.- The possible role of epigenetics in the memory impairment elicited by circadian rhythm disruption.- Circadian sleep-wake activity patterns during aging.- Effects of physical activity on circadian rhythms in the elderly.

Reviews

Author Information

S. Michal Jazwinski, Ph.D. is the John W. Deming, M.D. Regents Chair in Aging, Professor of Medicine, and Director of the Tulane Center for Aging at Tulane University.  His research on various aspects of aging has been funded by the National Institute on Aging (NIH) and private foundations, and it spans over thirty years.  It includes genetic studies in model organisms and multidisciplinary studies in humans. Victoria P. Belancio, Ph.D. is an Associate Professor of Structural and Cellular Biology at Tulane University. Her research on retrotransposon-associated genomic instability has been funded by the National Institute on Aging (NIH) and private foundations. It includes projects investigating how circadian disruption impacts DNA damage induced by retroelements and whether this damage influences mammalian aging. Steven M. Hill, Ph.D. is the Edmond and Lily Safra Chair for Breast Cancer Research, Professor of Structural & Cellular Biology, and Director of the Tulane Center for Circadian Biology at Tulane University.  His research on various aspects of circadian biology and breast cancer has been funded by the National Cancer Institute (NIH), the Army Department of Defense Breast Cancer Program, and private foundations, and spans over 25 years.   His recent research efforts have focused on the impact of circadian/melatonin disruption by light at night on human breast cancer progression, metastasis, and drug resistance.

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions