Overview

This text, containing contributions from an international team of experts in chronic myeloid leukaemia, examines the advances being made in our understanding of this disease, and the implications these have for its management. Topics covered include a review of molecular and cellular biology, discussion of conventional chemotherapy and interferon therapy, and developments in allografting and autografting.

Full Product Details

Author:   Angelo M Carella ,  George Q Daley ,  Connie J. Eaves (Terry Fox Laboratory, Vancouver, British Columbia, Canada) ,  John M Goldman (Hammersmith Hospital, London, UK)
Publisher:   Taylor & Francis Ltd
Imprint:   Informa Healthcare
Dimensions:   Width: 19.00cm , Height: 3.40cm , Length: 25.40cm
Weight:   1.678kg
ISBN:  

9781853178900

ISBN 10:   185317890
Pages:   500
Publication Date:   05 July 2001
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

Part 1. Molecular Biology: BCR/ABL Gene Structure and BCR Function. BCR/ABL Protein Domain Function and Signaling. Adhesion/Integrin Abnormalities. Animal Models. Progenitor Cell Dynamics. Target-Directed Therapies. Complementation of Cytokine Signaling Pathways. Part 2. Conventional Therapy: IFN Dosage Regimens. Chemotherapy vs IFN. Biology of IFN. Prognostic Scores in CML. Chemotherapy and Combination Chemotherapy. IFN and Ara-C. Part 3. Allografting: Donor Selection. Prognostic Factors. Timing. Conditioning Regimens. Blood vs Marrow Stem Cells. Results with Sibling/Alternative Donors. Monitoring. Relapse. Basis of GVL. Donor Lymphocyte Infusions. Part 4. Autografting: Genetic Approaches to Treatment of CML. Specific Chemical Inhibitors of ABL Tyrosine Kinase. Immunotherapeutic Strategies. Autografting with Unmanipulated Stem Cells. Autografting with Cultured Marrow. Autografting with Ph-Negative Hematopoietic Progenitor Cells. Long-term Follow-up of Autologous Transplant Therapy. Target-Directed Therapies and ST1571.

Reviews

This easy to read book is a timely and useful contribution to the literature and to the field for anyone involved in the care of patients with CML. The emphasis is clearly on treatment strategies which is a worthy focus since the options for CML patients have rapidly expanded and the decisions regarding the best treatment for a given patient have become complicated. The book constributes greatly towards providing the best treatment for each individual patient. --Martin S. Tallman, MD, Northwestern University Medical School, for Doody's Notes

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