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Author:   Yu Zhang
Publisher:   Springer Verlag, Singapore
Imprint:   Springer Verlag, Singapore
Edition:   2018 ed.
Volume:   1044
Weight:   3.702kg
ISBN:  

9789811305924

ISBN 10:   9811305927
Pages:   168
Publication Date:   18 July 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Chapter 1: Historical and clinical overview of chromosome translocations.- Chapter 2: Next generation sequencing to identify chromosome translocation.- Chapter 3: The experimental models to study chromosome translocations.- Chapter 4: High throughput translocation sequencing to identify mechanistic factors shaping translocatome.- Chapter 5: Live cell imaging to study chromosome translocation.- Chapter 6: CRISPR/Cas9 to induce chromosome translocation in vivo.- Chapter 7: Generation of DNA double strand breaks (DSBs).- Chapter 8: The role of DSB response pathway in regulating chromosome translocation.- Chapter 9: DSB repair and ligation of chromosome translocation.- Chapter 10: 3D genome organization defines the chromosome translocation pattern.- Chapter 11: Mechanisms of chromosome deletion.- Chapter 12: Chromothripsis: The role of DNA double strand break form on repair pathway selection.

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Author Information

Dr. Yu Zhang is Assistant Investigator at National Institute of Biological Sciences, Beijing, China.

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