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OverviewThis issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification. Full Product DetailsAuthor: B. Michael Ghadimi , Thomas RiedPublisher: Springer International Publishing AG Imprint: Springer International Publishing AG Edition: Softcover reprint of the original 1st ed. 2015 Volume: 200 Dimensions: Width: 15.50cm , Height: 1.20cm , Length: 23.50cm Weight: 3.577kg ISBN: 9783319349626ISBN 10: 3319349627 Pages: 224 Publication Date: 22 October 2016 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsDNA Repair and Chromosomal Translocations.- CINcere modelling: What have mouse models for chromosome instability taught us?.- Telomere Dysfunction, Chromosomal Instability and Cancer.- Genetic Instability and Disease Prognostication.- Causes of Chromosomal Instability.- Patterns of Chromosomal Aberrations in Solid Tumors.- Yeast as Models of Mitotic Fidelity.- The diverse effects of complex chromosome rearrangements and chromothripsis in cancer development.- Consequences of aneuploidy in cancer: transcriptome and beyond.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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