Overview

The last 15 years have witnessed significant developments in the efficiency and scope of the application of DKR. These now offer a serious alternative to conventional methods for asymmetric synthesis. Indeed, impressive examples using new enzymes and major progress in the DKR of racemates have taken place over the past few years. The powerful combination of enzymes and metals has also been the subject of spectacular development. In addition, a new type of DKR, involving organocatalysts, has recently appeared. Although asymmetric catalysis has undergone development during the last two decades, the most common industrial process used to obtain enantiomerically pure compounds is still via resolution of racemic mixtures. This is despite the major disadvantage that only a maximum of 50% product yield can be obtained. It is not surprising that DKR, which solves the problem of the limitation in yield, has attracted an increasing amount of interest from both the industrial and the academic perspective. This book provides an up-date on the principle methods employed to obtain dynamic kinetic resolution (DKR) by either enzymatic or non-enzymatic methods. It also illustrates the diversity of useful chiral products that can be obtained through this powerful concept. Divided into three sections, the book deals successively with non-enzymatic methods, enzymatic methods, and the use of transition metals and enzymes in tandem.

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9781849731973

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Reviews

'Throughout the text, the individual studies are summarizes in a paragraph or two, accompanied by a reaction scheme. This lends the text a readable structure with a reference-book level of utility. The majority of references are both recent and pertinent''a great reference to anyone working on DKR''through anthology of important and current DKR methodologies' * Ekaterina N. Kadnikova and Keegan G. Nelson * An engaging and clearly presented review of the current state of the art in dynamic kinetic resolution From an eye-catching, brightly coloured, front cover to well laid out text and schemes, the book is certainly visually appealing The Indexing is excellent Publication of this book is timely * Barry Potter *

"'Throughout the text, the individual studies are summarizes in a paragraph or two, accompanied by a reaction scheme. This lends the text a readable structure with a reference-book level of utility. The majority of references are both recent and pertinent''a great reference to anyone working on DKR''through anthology of important and current DKR methodologies' * Ekaterina N. Kadnikova and Keegan G. Nelson * ""An engaging and clearly presented review of the current state of the art in dynamic kinetic resolution""""From an eye-catching, brightly coloured, front cover to well laid out text and schemes, the book is certainly visually appealing""""The Indexing is excellent""""Publication of this book is timely"" * Barry Potter *"

'Throughout the text, the individual studies are summarizes in a paragraph or two, accompanied by a reaction scheme. This lends the text a readable structure with a reference-book level of utility. The majority of references are both recent and pertinent a great reference to anyone working on DKR through anthology of important and current DKR methodologies' Ekaterina N. Kadnikova and Keegan G. Nelson An engaging and clearly presented review of the current state of the art in dynamic kinetic resolution From an eye-catching, brightly coloured, front cover to well laid out text and schemes, the book is certainly visually appealing The Indexing is excellent Publication of this book is timely Barry Potter

Author Information

Hélène Pellissier was born in Gap, France. She carried out her PhD under the supervision of Dr G. Gil in Marseille and then entered the Centre National de la Recherche Scientifique in 1988. After a postdoctoral position in Professor K. P. C. Vollhardt's group at Berkeley, she joined the group of Professor M. Santelli in Marseille in 1992. Here she focused on the chemistry of BISTRO and its large application in organic synthesis.

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